Developmental Biology

SCRIB Rabbit Polyclonal Antibody (CAB17450)

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SKU:
CAB17450
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology
Synonyms:
CRIB1, SCRB1, SCRIB1, Vartul, oSCRIB, SCRIB
Research Use:
Developmental Biology
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Description

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SCRIB Antibody (CAB17450)

The SCRIB Antibody (CAB17450) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, has high reactivity with Scrib in human samples and is validated for use in Western blot applications. By binding to Scrib, this antibody allows for the detection and analysis of this protein in various cell types, making it ideal for studies in cell biology and cancer research.Scrib is a key player in cell polarity, which is essential for proper cell division and tissue organization. Dysregulation of Scrib has been implicated in various types of cancer, making it an important target for research aimed at understanding cancer development and progression.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.

Product Name:SCRIB Antibody
SKU:CAB17450
Size:20μL, 100μL
Reactivity:Human
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:ELCI QKAP GERL GISI RGGA RGHA GNPR DPTD EGIF ISKV SPTG AAGR DGRL RVGL RLLE VNQQ SLLG LTHG EAVQ LLRS VGDT LTVL VCDG FEAS TDAA LEVS PGVI ANPF AAGI GHRN SLES ISSI DREL SPEG PGKE KELP GQTL HWGP EATE AAGR GLQP LKLD YRAL AAVP SAGS VQRV PSGA AGGK MAES PCSP SGQQ PPSP PSPD ELPA NVKQ AYRA FAAV PTSH PPED APAQ PPTP GPAA SPEQ LSFR ERQK YFEL EVRV PQAE GPPK RVSL VGAD DLRK MQEE EARK LQQK R
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:1000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:CRIB1, SCRB1, SCRIB1, Vartul, oSCRIB, SCRIB
Positive Sample:MCF7
Cellular Localization:Basolateral Plasma Membrane, Extracellular Exosome, Extrinsic Component Of Postsynaptic Density Membrane, Glutamatergic Synapse, Immunological Synapse, Myelin Sheath Abaxonal Region, Nucleoplasm, Plasma Membrane, Postsynaptic Density, Presynapse, Scrib-Apc-Beta-Catenin Complex.
Calculated MW:175kDa
Observed MW:260kDa

This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

Purification MethodAffinity purification
Gene ID23513
RRIDAB_2772164
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of lysates from MCF7 cells, using SCRIB Rabbit pAb (CAB17450) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
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