Cell Biology Antibodies 13
Anti-CNTN1 Antibody (CAB17459)
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- SKU:
- CAB17459
Description
| Antibody Name: | Anti-CNTN1 Antibody |
| Antibody SKU: | CAB17459 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human CNTN1 (NP_778203.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human CNTN1 (NP_778203.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LECF ALGN PVPD IRWR KVLE PMPS TAEI STSG AVLK IFNI QLED EGIY ECEA ENIR GKDK HQAR IYVQ AFPE WVEH INDT EVDI GSDL YWPC VATG KPIP T |
| Gene ID: | 1272 |
| Uniprot: | Q12860 |
| Cellular Location: | |
| Calculated MW: | 70kDa/111kDa/113kDa |
| Observed MW: | 130kDa |
 | Western blot - CNTN1 Rabbit pAb (CAB17459) |
| Synonyms: | CNTN1, F3, GP135, MYPCN |
| Background: | The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| UniProt Protein Function: | CNTN1: Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth. Defects in CNTN1 are the cause of Compton-North congenital myopathy (CNCM). CNCM is a familial lethal form of congenital onset muscle weakness, inherited in an autosomal-recessive fashion and characterized by a secondary loss of beta2-syntrophin and alpha-dystrobrevin from the muscle sarcolemma, central nervous system involvement, and fetal akinesia. Belongs to the immunoglobulin superfamily. Contactin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 12q11-q12 Cellular Component: membrane Disease: Myopathy, Congenital, Compton-north |
| NCBI Summary: | The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q12860 |
| NCBI GenInfo Identifier: | 2497301 |
| NCBI Gene ID: | 1272 |
| NCBI Accession: | Q12860.1 |
| UniProt Secondary Accession: | Q12860,Q12861, Q14030, Q7M4P0, Q8N466, A8K0H9, A8K0Y3 |
| UniProt Related Accession: | Q12860 |
| Molecular Weight: | 70,604 Da |
| NCBI Full Name: | Contactin-1 |
| NCBI Synonym Full Names: | contactin 1 |
| NCBI Official Symbol: | CNTN1 |
| NCBI Official Synonym Symbols: | F3; GP135; MYPCN |
| NCBI Protein Information: | contactin-1 |
| UniProt Protein Name: | Contactin-1 |
| UniProt Synonym Protein Names: | Glycoprotein gp135; Neural cell surface protein F3 |
| Protein Family: | Contactin |
| UniProt Gene Name: | CNTN1 |
| UniProt Entry Name: | CNTN1_HUMAN |
Additional Information
Product Type: |
Antibody |
Reactivity: |
Human |
Reactivity: |
Mouse |
Reactivity: |
Rat |
Host Species: |
Rabbit |
Isotype: |
IgG |
Antibody Type: |
Polyclonal Antibody |
Research Area: |
Cell Biology |
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