Cell Death Antibodies 1

DNASE1 Rabbit Polyclonal Antibody (CAB2537)

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SKU:
CAB2537
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death
Antibody Type:
Polyclonal Antibody
Reactivity:
Human, Mouse, Rat
Synonyms:
DNL1, DRNI, DNASE1
Research Use:
Cell Death
Frequently bought together:

Description

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DNASE1 Antibody (CAB2537)

The DNASE1 Antibody (CAB2537) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in various applications including Western blotting. By binding to Deoxyribonuclease 1, this antibody enables accurate detection and analysis of the enzyme in different cell types, making it an excellent tool for studies in molecular biology and genetic research.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:DNASE1 Antibody
SKU:CAB2537
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:SLKI AAFN IQTF GETK MSNA TLVS YIVQ ILSR YDIA LVQE VRDS HLTA VGKL LDNL NQDA PDTY HYVV SEPL GRNS YKER YLFV YRPD QVSA VDSY YYDD GCEP CGND TFNR EPAI VRFF SRFT EVRE FAIV PLHA APGD AVAE IDAL YDVY LDVQ EKWG LEDV MLMG DFNA GCSY VRPS QWSS IRLW TSPT FQWL IPDS ADTT ATPT HCAY DRIV VAGM LLRG AVVP DSAL PFNF QAAY GLSD QLAQ AISD HYPV EVML K
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:1000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:DNL1, DRNI, DNASE1
Positive Sample:BxPC-3, SGC-7901, Mouse heart, Rat liver
Cellular Localization:Nucleus Envelope, Secreted.
Calculated MW:31kDa
Observed MW:32kDa

This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Purification MethodAffinity purification
Gene ID1773
RRIDAB_2764427
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using DNASE1 Rabbit pAb (CAB2537) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
Product ImageWestern blot analysis of various lysates using DNASE1 Rabbit pAb (CAB2537) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 180s.
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