Immunology Antibodies 2

CFP Rabbit Polyclonal Antibody (CAB5398)

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SKU:
CAB5398
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
Reactivity:
Human, Mouse, Rat
Synonyms:
BFD, PFC, PFD, PROPERDIN, CFP
Research Use:
Immunology
Frequently bought together:

Description

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CFP Antibody (CAB5398)

The CFP Antibody (CAB5398) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.Properdin, also known as factor P, is a positive regulator of the complement system, which plays a crucial role in immune defense against pathogens. Dysregulation of Properdin has been implicated in various inflammatory and autoimmune diseases, making it an important target for research in immunology and infectious diseases.

This antibody is validated for use in WB, IHC-P, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:CFP Antibody
SKU:CAB5398
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:CPTH GAWA TWGP WTPC SASC HGGP HEPK ETRS RKCS APEP SQKP PGKP CPGL AYEQ RRCT GLPP CPVA GGWG PWGP VSPC PVTC GLGQ TMEQ RTCN HPVP QHGG PFCA GDAT RTHI CNTA VPCP VDGE WDSW GEWS PCIR RNMK SISC QEIP GQQS RGRT CRGR KFDG HRCA GQQQ DIRH CYSI QHCP LKGS WSEW STWG LCMP PCGP NPTR ARQR LCTP LLPK YPPT VSMV EGQG EKNV TFWG RPLP RCEE LQGQ KLVV EEKR PCLH VPAC KDPE EEEL
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:
WB1:1000 - 1:5000
IHC-P1:50 - 1:200
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:BFD, PFC, PFD, PROPERDIN, CFP
Positive Sample:Human plasma
Cellular Localization:Secreted.
Calculated MW:51kDa
Observed MW:51kDa

This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Purification MethodAffinity purification
Gene ID5199
RRIDAB_2766207
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of lysates from Human plasma, using CFP Rabbit pAb (CAB5398) at 1:2000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
Product ImageImmunohistochemistry analysis of paraffin-embedded Human colon carcinoma using CFP Rabbit pAb (CAB5398) at dilution of 1:50 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
Product ImageImmunofluorescence analysis of U-2 OS cells using CFP Rabbit pAb (CAB5398) at dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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