Epigenetics & Nuclear Signaling Antibodies 1

UBR5 Rabbit Polyclonal Antibody (CAB13816)

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SKU:
CAB13816
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
Synonyms:
DD5, EDD, HYD, EDD1, UBR5
Research Use:
Epigenetics and Nuclear Signaling
Frequently bought together:

Description

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UBR5 Antibody (CAB13816)

The UBR5 Antibody (CAB13816) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. It binds specifically to the UBR5 protein, allowing for precise detection and analysis in various cell types.UBR5 is known to be a key regulator of cellular processes such as cell cycle progression, DNA repair, and apoptosis. Dysregulation of UBR5 has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.

Product Name:UBR5 Antibody
SKU:CAB13816
Size:20μL, 100μL
Reactivity:Human
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:SISA GIPK VGVL MESV WNMN DSCR FQLR SPES LKNM EKAS KTTE AKPE SKQE PVKT EMGP PPSP ASTC SDAS SIAS SASM PYKR RRST PAPK EEEK VNEE QWSL REVV FVED VKNV PVGK VLKV DGAY VAVK FPGT SSNT NCQN SSGP DADP SSLL QDCR LLRI DELQ VVKT GGTP KVPD CFQR TPKK LCIP EKTE ILAV NVDS KGVH AVL
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:DD5, EDD, HYD, EDD1, UBR5
Positive Sample:U-87MG, 293T, Jurkat, HeLa
Cellular Localization:Nucleus.
Calculated MW:309kDa
Observed MW:300kDa

This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.

Purification MethodAffinity purification
Gene ID51366
RRIDAB_2760671
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using UBR5 Rabbit pAb (CAB13816) at 1:3000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 60s.
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