Immunology Antibodies 1

MICA Rabbit Polyclonal Antibody (CAB12622)

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SKU:
CAB12622
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
Reactivity:
Human, Mouse
Synonyms:
MIC-A, PERB11.1, MICA
Research Use:
Immunology
Frequently bought together:

Description

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MICA Antibody (CAB12622)

The MICA Antibody (CAB12622) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the MICA protein, this antibody enables the detection and analysis of MICA expression in various cell types, making it ideal for studies in immunology and cancer research.MICA, also known as stress-induced MHC class I chain-related protein, is a key player in the immune response to stress and disease.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.

Product Name:MICA Antibody
SKU:CAB12622
Size:20μL, 100μL
Reactivity:Human, Mouse
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:EPHS LRYN LTVL SWDG SVQS GFLT EVHL DGQP FLRC DRQK CRAK PQGQ WAED VLGN KTWD RETR DLTG NGKD LRMT LAHI KDQK EGLH SLQE IRVC EIHE DNST RSSQ HFYY DGEL FLSQ NLET KEWT MPQS SRAQ TLAM NVRN FLKE DAMK TKTH YHAM HADC LQEL RRYL KSGV VLRR TVPP MVNV TRSE ASEG NITV TCRA SGFY PWNI TLSW RQDG VSLS HDTQ QWGD VLPD GNGT YQTW VATR ICQG EEQR FTCY MEHS GNHS THPV PSGK VLVL QSHW
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:MIC-A, PERB11.1, MICA
Positive Sample:K-562, Jurkat
Cellular Localization:Cell Membrane, Cytoplasm, Single-Pass Type I Membrane Protein.
Calculated MW:43kDa
Observed MW:50kDa

This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.

Purification MethodAffinity purification
Gene ID100507436
RRIDAB_2759467
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using MICA Rabbit pAb (CAB12622) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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