Cell Biology Antibodies 7

TIMP2 Rabbit Polyclonal Antibody (CAB16439)

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SKU:
CAB16439
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Reactivity:
Human, Mouse, Rat
Synonyms:
DDC8, CSC-21K, TIMP2
Research Use:
Cell Biology
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Description

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TIMP2 Antibody (CAB16439)

The TIMP2 Antibody (CAB16439) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting TIMP2 in human samples, making it ideal for use in Western blot applications.TIMP2 is a key regulator of matrix metalloproteinases (MMPs), enzymes that play essential roles in tissue remodeling, wound healing, and angiogenesis. Aberrant TIMP2 levels have been linked to various pathologies, including cardiovascular diseases, cancer metastasis, and neurological disorders.

This antibody is validated for use in WB, IHC-P, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:TIMP2 Antibody
SKU:CAB16439
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:VSLD VGGK KEYL IAGK AEGD GKMH ITLC DFIV PWDT LSTT QKKS LNHR YQMG CECK ITRC PMIP CYIS SPDE CLWM DWVT EKNI NGHQ AKFF ACIK RSDG S
Tested Applications:WB IHC-P ELISA
Recommended Dilution:
WB1:500 - 1:1000
IHC-P1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:DDC8, CSC-21K, TIMP2
Positive Sample:Mouse testis, Mouse brain, Rat testis
Cellular Localization:Secreted.
Calculated MW:24kDa
Observed MW:22kDa

This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.

Purification MethodAffinity purification
Gene ID7077
RRIDAB_2772615
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using TIMP2 Rabbit pAb (CAB16439) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1s.
Product ImageImmunohistochemistry analysis of paraffin-embedded Rat ovary using TIMP2 Rabbit pAb (CAB16439) at dilution of 1:100 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining.
Product ImageImmunohistochemistry analysis of paraffin-embedded Mouse pancreatic islet using TIMP2 Rabbit pAb (CAB16439) at dilution of 1:150 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining.
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