Cell Biology Antibodies 10

ISCU Rabbit Polyclonal Antibody (CAB7082)

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SKU:
CAB7082
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Synonyms:
HML, ISU2, NIFU, NIFUN, hnifU, 2310020H20Rik, ISCU
Research Use:
Cell Biology
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Description

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ISCU Antibody (CAB7082)

The ISCU Antibody (CAB7082) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, shows high reactivity with human samples and is specifically validated for use in Western blot applications. By binding to the ISCU protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in molecular biology and biochemistry.The ISCU protein plays a crucial role in cellular processes related to iron-sulfur cluster biogenesis, which are essential for various biological functions such as mitochondrial respiration and DNA repair.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.

Product Name:ISCU Antibody
SKU:CAB7082
Size:20μL, 100μL
Reactivity:Human
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:MAAA GAFR LRRA ASAL LLRS PRLP AREL SAPA RLYH KKVV DHYE NPRN VGSL DKTS KNVG TGLV GAPA CGDV MKLQ IQVD EKGK IVDA RFKT FGCG SAIA SSSL ATEW VKGK TVEE ALTI KNTD IAKE LCLP PVKL HCSM LAED AIKA ALAD YKLK QEPK KGEA EKK
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:HML, ISU2, NIFU, NIFUN, hnifU, 2310020H20Rik, ISCU
Positive Sample:HT-1080, U-87MG, 293T, A-549, HeLa
Cellular Localization:Cytoplasm, Mitochondrion, Nucleus.
Calculated MW:18kDa
Observed MW:14-18kDa

This gene encodes a component of the iron-sulfur (Fe-S) cluster scaffold. Fe-S clusters are cofactors that play a role in the function of a diverse set of enzymes, including those that regulate metabolism, iron homeostasis, and oxidative stress response. Alternative splicing results in transcript variants encoding different protein isoforms that localize either to the cytosol or to the mitochondrion. Mutations in this gene have been found in patients with hereditary myopathy with lactic acidosis. A disease-associated mutation in an intron may activate a cryptic splice site, resulting in the production of a splice variant encoding a putatively non-functional protein. A pseudogene of this gene is present on chromosome 1.

Purification MethodAffinity purification
Gene ID23479
RRIDAB_2767637
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using ISCU Rabbit pAb (CAB7082) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 10s.
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