Developmental Biology

SIM2 Rabbit Polyclonal Antibody (CAB15098)

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SKU:
CAB15098
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology
Reactivity:
Human, Mouse, Rat
Synonyms:
SIM, bHLHe15, HMC13F06, HMC29C01, SIM2
Research Use:
Developmental Biology
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Description

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SIM2 Antibody (CAB15098)

The SIM2 Antibody (CAB15098) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, developed using rabbit immunization, is highly specific to human samples and has been validated for use in applications such as Western blotting.SIM2, a transcriptional regulator involved in brain development and function, has been implicated in various neurological disorders, making it a promising target for research in neuroscience and neurodegenerative diseases.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:SIM2 Antibody
SKU:CAB15098
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:LSLE QVST AKSQ DSWR TALS TSQE TRKL VKPK NTKM KTKL RTNP YPPQ QYSS FQMD KLEC GQLG NWRA SPPA SAAA PPEL QPHS ESSD LLYT PSYS LPFS YHYG HFPL DSHV FSSK KPML PAKF GQPQ GSPC EVAR FFLS TLPA SGEC QWHY ANPL VPSS SSPA KNPP EPPA NTAR HSLV PSYE
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:SIM, bHLHe15, HMC13F06, HMC29C01, SIM2
Positive Sample:HepG2, PC-3, Mouse kidney
Cellular Localization:Nucleus.
Calculated MW:73kDa
Observed MW:73kDa

This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants.

Purification MethodAffinity purification
Gene ID6493
RRIDAB_2761982
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates, using SIM2 Rabbit pAb (CAB15098) at 1:400 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 60s.
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