Epigenetics & Nuclear Signaling Antibodies 1

PDX1 Rabbit Polyclonal Antibody (CAB10173)

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SKU:
CAB10173
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
Reactivity:
Human, Mouse
Synonyms:
GSF, IPF1, IUF1, IDX-1, MODY4, PDX-1, STF-1, PAGEN1, PDX1
Research Use:
Epigenetics and Nuclear Signaling
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Description

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PDX1 Antibody (CAB10173)

The PDX1 Antibody (CAB10173) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.PDX1, also known as insulin promoter factor 1, plays a crucial role in regulating the expression of genes involved in insulin production and glucose metabolism.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.

Product Name:PDX1 Antibody
SKU:CAB10173
Size:20μL, 100μL
Reactivity:Human, Mouse
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:MNGE EQYY AATQ LYKD PCAF QRGP APEF SASP PACL YMGR QPPP PPPH PFPG ALGA LEQG SPPD ISPY EVPP LADD PAVA HLHH HLPA QLAL PHPP AGPF
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:1000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:GSF, IPF1, IUF1, IDX-1, MODY4, PDX-1, STF-1, PAGEN1, PDX1
Positive Sample:DU145, HepG2, Mouse pancreas, Mouse liver
Cellular Localization:Cytoplasm, Nucleus, Cytosol.
Calculated MW:31kDa
Observed MW:39kDa

The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (IDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

Purification MethodAffinity purification
Gene ID3651
RRIDAB_2757700
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using PDX1 Rabbit pAb (CAB10173) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
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