Epigenetics & Nuclear Signaling Antibodies 1

PATZ1 Rabbit Polyclonal Antibody (CAB10053)

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SKU:
CAB10053
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
Reactivity:
Human, Mouse, Rat
Synonyms:
ZSG, MAZR, PATZ, RIAZ, ZBTB19, ZNF278, dJ400N23, PATZ1
Research Use:
Epigenetics and Nuclear Signaling
Frequently bought together:

Description

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PATZ1 Antibody (CAB10053)

The PATZ1 Antibody (CAB10053) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blot applications.PATZ1, also known as MAZR, is known to play a role in various cellular processes, including cell proliferation, differentiation, and apoptosis. Its dysregulation has been associated with the development of cancer and other diseases, making it a target of interest in cancer research and beyond.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:PATZ1 Antibody
SKU:CAB10053
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:PFPS VASS APPL TGKR GRGR PRKA NLLD SMFG SPGG LREA GILP CGLC GKVF TDAN RLRQ HEAQ HGVT SLQL GYID LPPP RLGE NGLP ISED PDGP RKRS R
Tested Applications:WB ELISA
Recommended Dilution:
WB1:1000 - 1:5000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:ZSG, MAZR, PATZ, RIAZ, ZBTB19, ZNF278, dJ400N23, PATZ1
Positive Sample:HeLa, A-549, Mouse kidney, Rat kidney
Cellular Localization:Nucleus.
Calculated MW:74kDa
Observed MW:74kDa

The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.

Purification MethodAffinity purification
Gene ID23598
RRIDAB_2757574
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates, using PATZ1 Rabbit pAb (CAB10053) at 1:2000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
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