Cell Death Antibodies 1

Mitofusin 2 Rabbit Polyclonal Antibody (CAB12771)

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SKU:
CAB12771
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
Reactivity:
Human, Mouse, Rat
Synonyms:
HSG, MARF, CMT2A, CPRP1, CMT2A2, HMSN6A, CMT2A2A, CMT2A2B, Mitofusin 2
Research Use:
Cell Death
Frequently bought together:

Description

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Mitofusin 2 Antibody (CAB12771)

The Mitofusin 2 Antibody (CAB12771) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to MFN2, this antibody allows for the detection and analysis of MFN2 protein levels in a variety of cell types.MFN2 is a key player in mitochondrial dynamics, playing a crucial role in maintaining mitochondrial function and regulating processes such as apoptosis and metabolism. Dysregulation of MFN2 has been implicated in a variety of diseases, including neurodegenerative disorders and metabolic syndromes.

This antibody is validated for use in WB, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:Mitofusin 2 Antibody
SKU:CAB12771
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:TTEE QVLD VKGY LSKV RGIS EVLA RRHM KVAF FGRT SNGK STVI NAML WDKV LPSG IGHT TNCF LRVE GTDG HEAF LLTE GSEE KRSA KTVN QLAH ALHQ DKQL HAGS LVSV MWPN SKCP LLKD DLVL MDSP GIDV TTEL DSWI DKFC LDAD VFVL VANS ESTL MQTE KHFF HKVS ERLS RPNI FILN NRW
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:1000
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:HSG, MARF, CMT2A, CPRP1, CMT2A2, HMSN6A, CMT2A2A, CMT2A2B, Mitofusin 2
Positive Sample:Rat brain
Cellular Localization:Mitochondrion Outer Membrane, Multi-Pass Membrane Protein.
Calculated MW:86kDa
Observed MW:80kDa

This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.

Purification MethodAffinity purification
Gene ID9927
RRIDAB_2759615
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of lysates from Rat brain, using Mitofusin 2 Rabbit pAb (CAB12771) at 1:400 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
Product ImageImmunofluorescence analysis of HeLa cells using Mitofusin 2 Rabbit pAb (CAB12771) at dilution of 1:50 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
Product ImageImmunofluorescence analysis of HeLa cells using Mitofusin 2 Rabbit pAb (CAB12771) at dilution of 1:50 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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