Cell Death Antibodies 2

Caspase-2 Rabbit Polyclonal Antibody (CAB5724)

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SKU:
CAB5724
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
Reactivity:
Human, Mouse, Rat
Synonyms:
ICH1, NEDD2, CASP-2, NEDD-2, PPP1R57, Caspase-2
Research Use:
Cell Death
Frequently bought together:

Description

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Caspase-2 Antibody (CAB5724)

The Caspase-2 Antibody (CAB5724) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blot applications.Caspase-2 is known for its involvement in various cellular processes, including DNA repair, cell cycle regulation, and cell death. Dysregulation of caspase-2 has been linked to a variety of diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:Caspase-2 Antibody
SKU:CAB5724
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:KLRL STDT VEHS LDNK DGPV CLQV KPCT PEFY QTHF QLAY RLQS RPRG LALV LSNV HFTG EKEL EFRS GGDV DHST LVTL FKLL GYDV HVLC DQTA QEMQ EKLQ NFAQ LPAH RVTD SCIV ALLS HGVE GAIY GVDG KLLQ LQEV FQLF DNAN CPSL QNKP KMFF IQAC RGDE TDRG VDQQ DGKN HAGS PGCE ESDA GKEK LPKM RLPT RSDM ICGY ACLK GTAA MRNT KRGS WYIE ALAQ VFSE RACD MHVA DMLV KVNA LIKD REGY APGT EFHR CKEM SEYC STLC RHLY LFPG HPPT
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:ICH1, NEDD2, CASP-2, NEDD-2, PPP1R57, Caspase-2
Positive Sample:Jurkat treated with Staurosporine, Rat brain
Cellular Localization:Cytoplasm, Cytosol, Mitochondrion, Nucleolus, Nucleus.
Calculated MW:51kDa
Observed MW:48kDa

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Purification MethodAffinity purification
Gene ID835
RRIDAB_2766481
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using Caspase-2 Rabbit pAb (CAB5724) at 1:1000 dilution. Jurkat cells were treated with Staurosporine(1uM) at room temperature for 3 hours . Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 3min.
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