Caveolin-2 Rabbit Polyclonal Antibody (CAB20549)

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SKU:
CAB20549
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
Reactivity:
Human, Mouse, Rat
Synonyms:
CAV, Caveolin-2
Research Use:
Cell Biology
Frequently bought together:

Description

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Caveolin-2 Antibody (CAB20549)

The Caveolin-2 Antibody (CAB20549) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, is highly specific for human samples and is validated for use in Western blot applications.Caveolin-2 is a structural component of caveolae, small invaginations in the plasma membrane that play a role in various cellular processes, including endocytosis, signal transduction, and cholesterol homeostasis. Studies have shown that Caveolin-2 is implicated in cancer progression, cardiovascular diseases, and neurodegenerative disorders, making it a promising target for therapeutic interventions.

This antibody is validated for use in WB, IHC-P, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:Caveolin-2 Antibody
SKU:CAB20549
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:MGLE TEKA DVQL FMDD DSYS HHSG LEYA DPEK FADS DQDR DPHR LNSH LKLG FEDV IAEP VTTH S
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:1000
IHC-P1:50 - 1:200
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:CAV, Caveolin-2
Positive Sample:HeLa, Mouse lung
Cellular Localization:Cell Membrane, Cytoplasm, Golgi Apparatus Membrane, Membrane, Nucleus, Peripheral Membrane Protein, Caveola.
Calculated MW:18kDa
Observed MW:21kDa

The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462).

Purification MethodAffinity purification
Gene ID858
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using Caveolin-2 Rabbit pAb (CAB20549) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1s.
Product ImageImmunohistochemistry analysis of paraffin-embedded Rat brain using Caveolin-2 Rabbit pAb (CAB20549) at dilution of 1:100 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
Product ImageImmunofluorescence analysis of NIH/3T3 cells using Caveolin-2 Rabbit pAb (CAB20549) at dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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