Epigenetics & Nuclear Signaling Antibodies 1

MGMT Rabbit Polyclonal Antibody (CAB0693)

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SKU:
CAB0693
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
Reactivity:
Human, Mouse
Synonyms:
MGMT
Research Use:
Epigenetics and Nuclear Signaling
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Description

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MGMT Antibody (CAB0693)

The MGMT Antibody (CAB0693) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the MGMT protein, it allows for accurate detection and analysis, making it ideal for studies in oncology and drug resistance research.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.

Product Name:MGMT Antibody
SKU:CAB0693
Size:20μL, 100μL
Reactivity:Human, Mouse
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:MLGQ PAPL ERFA SRRP QVLA VRTV CDLV LGKM DKDC EMKR TTLD SPLG KLEL SGCE QGLH EIKL LGKG TSAA DAVE VPAP AAVL GGPE PLMQ CTAW LNAY FHQP EAIE EFPV PALH HPVF QQES FTRQ VLWK LLKV VKFG EVIS YQQL AALA GNPK AARA VGGA MRGN PVPI LIPC HRVV CSSG AVGN YSGG LAVK EWLL AHEG HRL
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:1000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:MGMT
Positive Sample:Jurkat, Mouse liver, Mouse spleen
Cellular Localization:Nucleus.
Calculated MW:22kDa
Observed MW:22kDa

Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma.

Purification MethodAffinity purification
Gene ID4255
RRIDAB_2757344
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using MGMT Rabbit pAb (CAB0693) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 180s.
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