Epigenetics & Nuclear Signaling Antibodies 1

HDAC4 Rabbit Polyclonal Antibody (CAB0239)

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SKU:
CAB0239
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
Synonyms:
HD4, AHO3, BDMR, HDACA, HA6116, HDAC-4, HDAC-A, NEDCHF, NEDCHID, HDAC4
Research Use:
Epigenetics and Nuclear Signaling
Frequently bought together:

Description

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HDAC4 Antibody (CAB0239)

The HDAC4 Antibody (CAB0239) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to HDAC4, the antibody allows for accurate detection and analysis of this important protein in various cell types.HDAC4 is known to play a crucial role in gene expression, cell differentiation, and cell survival, making it a promising target for research in various fields, including cancer biology, neurology, and cardiovascular diseases.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.

Product Name:HDAC4 Antibody
SKU:CAB0239
Size:20μL, 100μL
Reactivity:Human
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:REHQ ALLD EPYL DRLP GQKE AHAQ AGVQ VKQE PIES DEEE AEPP REVE PGQR QPSE QELL FRQQ ALLL EQQR IHQL RNYQ ASME AAGI PVSF GGHR PLSR A
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:1000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:HD4, AHO3, BDMR, HDACA, HA6116, HDAC-4, HDAC-A, NEDCHF, NEDCHID, HDAC4
Positive Sample:HeLa
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:119kDa
Observed MW:140kDa

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.

Purification MethodAffinity purification
Gene ID9759
RRIDAB_2757052
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates, using HDAC4 Rabbit pAb (CAB0239) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
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