Epigenetics & Nuclear Signaling Antibodies 1

HDAC4 Rabbit Polyclonal Antibody (CAB0179)

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SKU:
CAB0179
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
Reactivity:
Human, Mouse, Rat
Synonyms:
HD4, AHO3, BDMR, HDACA, HA6116, HDAC-4, HDAC-A, NEDCHF, NEDCHID, HDAC4
Research Use:
Epigenetics and Nuclear Signaling
Frequently bought together:

Description

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HDAC4 Antibody (CAB0179)

The HDAC4 Antibody (CAB0179) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. It binds specifically to the HDAC4 protein, allowing for precise detection and analysis in a variety of cell types.HDAC4, a histone deacetylase, plays a crucial role in the regulation of gene expression and has been implicated in various diseases, including cancer and neurodegenerative disorders.

This antibody is validated for use in WB, IHC-P, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:HDAC4 Antibody
SKU:CAB0179
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:PSIH KLRQ HRPL GRTQ SAPL PQNA QALQ HLVI QQQH QQFL EKHK QQFQ QQQL QMNK IIPK PSEP ARQP ESHP EETE EELR EHQA LLDE PYLD RLPG QKEA HAQA GVQV KQEP IESD EEEA EPPR EVEP GQRQ PSEQ ELLF RQQA LLLE QQRI HQLR NYQA SMEA AGIP VSFG GHRP LSRA QSSP ASAT FPVS VQEP PTKP
Tested Applications:WB IHC-P ELISA
Recommended Dilution:
WB1:500 - 1:1000
IHC-P1:50 - 1:100
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:HD4, AHO3, BDMR, HDACA, HA6116, HDAC-4, HDAC-A, NEDCHF, NEDCHID, HDAC4
Positive Sample:HeLa
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:119kDa
Observed MW:140kDa

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.

Purification MethodAffinity purification
Gene ID9759
RRIDAB_2757003
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using HDAC4 Rabbit pAb (CAB0179) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Negative control (NC): U-2 OS. Exposure time: 60s.
Product ImageImmunohistochemistry analysis of paraffin-embedded Human stomach using HDAC4 Rabbit pAb (CAB0179) at dilution of 1:100 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining.
Product ImageImmunohistochemistry analysis of paraffin-embedded Mouse brain using HDAC4 Rabbit pAb (CAB0179) at dilution of 1:100 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining.
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