Epigenetics & Nuclear Signaling Antibodies 5

HDAC4 Rabbit Monoclonal Antibody (CAB13510)

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SKU:
CAB13510
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
Reactivity:
Human
Synonyms:
HD4, AHO3, BDMR, HDACA, HA6116, HDAC-4, HDAC-A, NEDCHF, NEDCHID, HDAC4
Research Use:
Epigenetics and Nuclear Signaling
Frequently bought together:

Description

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HDAC4 Monoclonal Antibody (CAB13510)

The HDAC4 Monoclonal Antibody (CAB13510) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting HDAC4 in human samples, making it an ideal choice for Western blot and immunohistochemistry applications.HDAC4 is a key player in epigenetic regulation, influencing gene expression by modifying chromatin structure. Dysregulation of HDAC4 has been linked to various diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.

Product Name:HDAC4 Monoclonal Antibody
SKU:CAB13510
Size:20μL, 100μL
Reactivity:Human
Clone Number:ARC0714
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:MSSQ SHPD GLSG RDQP VELL NPAR VNHM PSTV DVAT ALPL QVAP SAVP MDLR LDHQ FSLP VAEP ALRE QQLQ QELL ALKQ KQQI QRQI LIAE FQRQ HEQL
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:1000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:HD4, AHO3, BDMR, HDACA, HA6116, HDAC-4, HDAC-A, NEDCHF, NEDCHID, HDAC4
Positive Sample:Jurkat, THP-1
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:119kDa
Observed MW:140kDa

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.

Purification MethodAffinity purification
Gene ID9759
RRIDAB_2861688
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates, using HDAC4 Rabbit mAb (CAB13510) at 1:500 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 60s.
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