Cell Biology Antibodies 13

UBE4B Rabbit Polyclonal Antibody (CAB17609)

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SKU:
CAB17609
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Reactivity:
Human, Mouse
Synonyms:
E4, UFD2, HDNB1, UBOX3, UFD2A, UBE4B
Research Use:
Cell Biology
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Description

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UBE4B Antibody (CAB17609)

The UBE4B Antibody (CAB17609) is a high-quality antibody developed for reliable detection and analysis of target proteins. This rabbit polyclonal antibody is highly specific for human samples and has been validated for use in Western blot applications.UBE4B plays a crucial role in maintaining cellular homeostasis by targeting proteins for degradation through the ubiquitin-proteasome system. Dysregulation of UBE4B has been implicated in various diseases, including cancer and neurodegenerative disorders.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.

Product Name:UBE4B Antibody
SKU:CAB17609
Size:20μL, 100μL
Reactivity:Human, Mouse
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:EVDE NDRR EKRS LSDK EPSS GPEV SEEQ ALQL VCKI FRVS WKDR DRDV IFLS SLSA QFKQ NPKE VFSD FKDL IGQI LMEV LMMS TQTR DENP FASL TATS QPIA AAAR SPDR NLLL NTGS N
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:E4, UFD2, HDNB1, UBOX3, UFD2A, UBE4B
Positive Sample:Raji, OVCAR3, HeLa, Mouse testis
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:146kDa
Observed MW:146kDa

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Purification MethodAffinity purification
Gene ID10277
RRIDAB_2772785
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using UBE4B Rabbit pAb (CAB17609) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
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