Anti-TUG/ASPSCR1 Antibody (CAB1396)
- SKU:
- CAB1396
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ASPSCR1
- Synonyms:
- ASPCR1
- Synonyms:
- ASPL
- Synonyms:
- ASPS
- Synonyms:
- RCC17
- Synonyms:
- TUG
- Synonyms:
- UBXD9
- Synonyms:
- UBXN9
- Synonyms:
- tether containing UBX domain for GLUT4
- Research Area:
- Cell Biology
Description
| Product Name: | TUG/ASPSCR1 Rabbit mAb |
| Product Code: | CAB1396 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ASPSCR1, ASPCR1, ASPL, ASPS, RCC17, TUG, UBXD9, UBXN9, tether containing UBX domain for GLUT4 |
| Applications: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human TUG/ASPSCR1. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T, NIH/3T3, RD, Mouse testis |
| Immunogen: | A synthesized peptide derived from human TUG/ASPSCR1. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 79058 |
| Uniprot: | Q9BZE9 |
| Cellular Location: | Cytoplasm, Endomembrane system, Endoplasmic reticulum-Golgi intermediate compartment membrane, Nucleus, Peripheral membrane protein |
| Calculated MW: | 70-80kDa |
| Observed MW: | 75KDa |
| UniProt Protein Function: | ASPSCR1: Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Interacts with GLUT4. Ubiquitous. Highly expressed in testis, heart, skeletal muscle and pancreas. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oncoprotein; Membrane protein, peripheral; Vesicle Chromosomal Location of Human Ortholog: 17q25.3 Cellular Component: intracellular membrane-bound organelle; nucleoplasm; plasma membrane Molecular Function:protein binding Disease: Alveolar Soft Part Sarcoma |
| NCBI Summary: | The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X;17)(p11;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2011] |
| UniProt Code: | Q9BZE9 |
| NCBI GenInfo Identifier: | 74717746 |
| NCBI Gene ID: | 79058 |
| NCBI Accession: | Q9BZE9.1 |
| UniProt Secondary Accession: | Q9BZE9,Q7Z6N7, Q8WV59, Q96LS5, Q96M40, A8K3K9, |
| UniProt Related Accession: | Q9BZE9 |
| Molecular Weight: | 37,910 Da |
| NCBI Full Name: | Tether containing UBX domain for GLUT4 |
| NCBI Synonym Full Names: | ASPSCR1, UBX domain containing tether for SLC2A4 |
| NCBI Official Symbol: | ASPSCR1 |
| NCBI Official Synonym Symbols: | TUG; ASPL; ASPS; RCC17; UBXD9; UBXN9; ASPCR1 |
| NCBI Protein Information: | tether containing UBX domain for GLUT4 |
| UniProt Protein Name: | Tether containing UBX domain for GLUT4 |
| UniProt Synonym Protein Names: | Alveolar soft part sarcoma chromosomal region candidate gene 1 protein; Alveolar soft part sarcoma locus; Renal papillary cell carcinoma protein 17; UBX domain-containing protein 9 |
| Protein Family: | Tether containing UBX domain |
| UniProt Gene Name: | ASPSCR1 |
| UniProt Entry Name: | ASPC1_HUMAN |
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