Cell Biology Antibodies 8

TMPRSS2 Rabbit Polyclonal Antibody (CAB1979)

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SKU:
CAB1979
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
Antibody Type:
Polyclonal Antibody
Reactivity:
Human, Mouse, Rat
Synonyms:
PRSS10, TMPRSS2
Research Use:
Cell Biology
Frequently bought together:

Description

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TMPRSS2 Antibody (CAB1979)

The TMPRSS2 Antibody (CAB1979) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, derived from rabbit immunization, is highly specific to human samples and has been validated for use in Western blot applications.TMPRSS2 is known for its role in viral infections, particularly in facilitating the entry of certain viruses into host cells. By targeting the TMPRSS2 protein, researchers can investigate its involvement in viral pathogenesis and explore potential therapeutic interventions for viral diseases.

This antibody is validated for use in WB, IHC-P, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:TMPRSS2 Antibody
SKU:CAB1979
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:MALN SGSP PAIG PYYE NHGY QPEN PYPA QPTV VPTV YEVH PAQY YPSP VPQY APRV LTQA SNPV VCTQ PKSP SGTV CTSK TKKA LCIT LTLG TFLV GAAL
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:1000
IHC-P1:50 - 1:200
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:PRSS10, TMPRSS2
Positive Sample:Mouse kidney, Mouse stomach, Rat large intestine, Rat lung, Rat kidney
Cellular Localization:Cell Membrane, Secreted, Single-Pass Type Ii Membrane Protein.
Calculated MW:54kDa
Observed MW:70kDa/32kDa

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Purification MethodAffinity purification
Gene ID7113
RRIDAB_2764005
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using TMPRSS2 Rabbit pAb (CAB1979) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 180s.
Product ImageImmunohistochemistry analysis of paraffin-embedded Human breast cancer using TMPRSS2 Rabbit pAb (CAB1979) at dilution of 1:50 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
Product ImageImmunofluorescence analysis of A-549 cells using TMPRSS2 Rabbit pAb (CAB1979) at dilution of 1:50 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
Product ImageImmunofluorescence analysis of C6 cells using TMPRSS2 Rabbit pAb (CAB1979) at dilution of 1:50 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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