Cell Biology Antibodies 12

TIMM8A Rabbit Polyclonal Antibody (CAB9811)

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SKU:
CAB9811
Product Type:
Antibody
Applications:
WB
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
Antibody Type:
Polyclonal Antibody
Reactivity:
Human, Mouse, Rat
Synonyms:
DDP, MTS, DDP1, DFN1, TIM8, TIMM8A
Research Use:
Cell Biology
Frequently bought together:

Description

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TIMM8A Antibody (CAB9811)

The TIMM8A Antibody (CAB9811) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the TIMM8A protein, this antibody enables researchers to detect and analyze TIMM8A in a variety of cell types, making it ideal for studies in mitochondrial biology and related research areas.TIMM8A is a key component of the TIMM complex, responsible for importing nuclear-encoded proteins into the mitochondria.

This antibody is validated for use in WB, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:TIMM8A Antibody
SKU:CAB9811
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:MDSS SSSS AAGL GAVD PQLQ HFIE VETQ KQRF QQLV HQMT ELCW EKCM DKPG PKLD SRAE ACFV NCVE RFID TSQF ILNR LEQT QKSK PVFS ESLS D
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:2000
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:DDP, MTS, DDP1, DFN1, TIM8, TIMM8A
Positive Sample:U-87MG
Cellular Localization:Intermembrane Side, Mitochondrion Inner Membrane, Peripheral Membrane Protein.
Calculated MW:11kDa
Observed MW:11kDa

This translocase is involved in the import and insertion of hydrophobic membrane proteins from the cytoplasm into the mitochondrial inner membrane. The gene is mutated in Mohr-Tranebjaerg syndrome/Deafness Dystonia Syndrome (MTS/DDS) and it is postulated that MTS/DDS is a mitochondrial disease caused by a defective mitochondrial protein import system. Defects in this gene also cause Jensen syndrome; an X-linked disease with opticoacoustic nerve atrophy and muscle weakness. This protein, along with TIMM13, forms a 70 kDa heterohexamer. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Purification MethodAffinity purification
Gene ID1678
RRIDAB_2772614
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of lysates from U-87MG cells, using TIMM8A Rabbit pAb (CAB9811) at 1:600 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 90s.
Product ImageImmunofluorescence analysis of C6 cells using TIMM8A Rabbit pAb (CAB9811) at dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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