Metabolism Antibodies 2

SQS/FDFT1 Rabbit Polyclonal Antibody (CAB6229)

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SKU:
CAB6229
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
Reactivity:
Human, Mouse, Rat
Synonyms:
SS, SQS, DGPT, ERG9, SQSD, SQS/FDFT1
Research Use:
Metabolism
Frequently bought together:

Description

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SQS/FDFT1 Antibody (CAB6229)

The SQS/FDFT1 Antibody (CAB6229) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, raised in rabbits, is highly specific for human squalene synthase and has been validated for use in Western blot applications.Squalene synthase plays a crucial role in the cholesterol biosynthetic pathway, making it a promising target for therapies aimed at treating dyslipidemia and other related disorders. By detecting and analyzing squalene synthase expression in various cell types, this antibody can provide insights into the regulation of cholesterol synthesis and potential drug targets for cardiovascular diseases and metabolic disorders.

This antibody is validated for use in WB, IHC-P, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:SQS/FDFT1 Antibody
SKU:CAB6229
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:MEFV KCLG HPEE FYNL VRFR IGGK RKVM PKMD QDSL SSSL KTCY KYLN QTSR SFAA VIQA LDGE MRNA VCIF YLVL RALD TLED DMTI SVEK KVPL LHNF HSFL YQPD WRFM ESKE KDRQ VLED FPTI SLEF RNLA EKYQ TVIA DICR RMGI GMAE FLDK HVTS EQEW DKYC HYVA GLVG IGLS RLFS ASEF EDPL VGED TERA NSMG LFLQ KTNI IRDY LEDQ QGGR EFWP QEVW SRYV KKLG DFAK PENI DLAV QCLN
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:1000
IHC-P1:50 - 1:200
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:SS, SQS, DGPT, ERG9, SQSD, SQS/FDFT1
Positive Sample:HeLa, Jurkat
Cellular Localization:Endoplasmic Reticulum Membrane, Multi-Pass Membrane Protein.
Calculated MW:48kDa
Observed MW:48kDa

This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.

Purification MethodAffinity purification
Gene ID2222
RRIDAB_2766838
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using SQS/FDFT1 Rabbit pAb (CAB6229) at 1:500 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 1s.
Product ImageImmunohistochemistry analysis of paraffin-embedded Mouse testis using SQS/FDFT1 Rabbit pAb (CAB6229) at dilution of 1:100 (20x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining.
Product ImageImmunofluorescence analysis of NIH-3T3 cells using SQS/FDFT1 Rabbit pAb (CAB6229) at dilution of 1:100. Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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