Immunology Antibodies 2

SKAP2 Rabbit Polyclonal Antibody (CAB15750)

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SKU:
CAB15750
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
Reactivity:
Human, Mouse, Rat
Synonyms:
PRAP, RA70, SAPS, SCAP2, SKAP55R, SKAP-HOM, SKAP2
Research Use:
Immunology
Frequently bought together:

Description

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SKAP2 Antibody (CAB15750)

The SKAP2 Antibody (CAB15750) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the SKAP2 protein, researchers can delve into the mechanisms underlying immune cell activation and potentially uncover new therapeutic targets for immune-related disorders.SKAP2 is a signaling adaptor protein that is involved in T cell receptor signaling and immune synapse formation. Its binding to other proteins in the signaling cascade helps modulate immune responses and regulate T cell activation.

This antibody is validated for use in WB, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:SKAP2 Antibody
SKU:CAB15750
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:MPNP SSTS SPYP LPEE IRNL LADV ETFV ADIL KGEN LSKK AKEK RESL IKKI KDVK SIYL QEFQ DKGD AEDG EEYD DPFA GPPD TISL ASER YDKD DEAP SDGA QFPP IAAQ DLPF VLKA
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:2000
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:PRAP, RA70, SAPS, SCAP2, SKAP55R, SKAP-HOM, SKAP2
Positive Sample:Mouse lung
Cellular Localization:Cytoplasm.
Calculated MW:41kDa
Observed MW:45kDa

The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms.

Purification MethodAffinity purification
Gene ID8935
RRIDAB_2763167
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of lysates from Mouse lung, using SKAP2 Rabbit pAb (CAB15750) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
Product ImageImmunofluorescence analysis of MCF7 cells using SKAP2 Rabbit pAb (CAB15750). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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