Epigenetics & Nuclear Signaling Antibodies 1

Reptin/RUVBL2 Rabbit Polyclonal Antibody (CAB12564)

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SKU:
CAB12564
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
Reactivity:
Human, Mouse, Rat
Synonyms:
RVB2, TIH2, ECP51, TIP48, CGI-46, ECP-51, INO80J, REPTIN, TIP49B, TAP54-beta, Reptin/RUVBL2
Research Use:
Epigenetics and Nuclear Signaling
Frequently bought together:

Description

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Reptin/RUVBL2 Antibody (CAB12564)

The Reptin/RUVBL2 Antibody (CAB12564) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, demonstrates high specificity and sensitivity towards human samples, making it suitable for Western blot applications.RUVBL2, also known as pontin or reptin, is a member of the AAA+ ATPase family and is known to interact with a wide range of proteins involved in transcriptional regulation, DNA repair, and chromatin remodeling. Its diverse functions make it a key player in cellular homeostasis and its dysregulation has been implicated in various diseases, including cancer and neurodegenerative disorders.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:Reptin/RUVBL2 Antibody
SKU:CAB12564
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:MATV TATT KVPE IRDV TRIE RIGA HSHI RGLG LDDA LEPR QASQ GMVG QLAA RRAA GVVL EMIR EGKI AGRA VLIA GQPG TGKT AIAM GMAQ ALGP DTPF TAIA GSEI FSLE MSKT EALT QAFR RSIG VRIK EETE IIEG EVVE IQID RPAT GTGS KVGK LTLK TTEM ETIY DLGT KMIE SLTK DKVQ AGDV ITID KATG KISK LGRS FTRA RDYD AMGS QTKF VQCP DGEL QKRK EVVH TVSL HEID VINS RTQG FLAL FSGD TGEI KSEV REQI NAKV AEWR EEGK AEII PGVL FIDE VHML DIES FSFL NRAL ESDM APVL IMAT NRGI TRIR GTSY QSPH GIPI DLLD RLLI VSTT PYSE KDTK QILR IRCE EEDV EMSE DAYT VLTR IGLE TSLR YAIQ LITA ASLV CRKR KGTE VQVD DIKR VYSL FLDE SRST QYMK EYQD AFLF NELK GETM DTS
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:RVB2, TIH2, ECP51, TIP48, CGI-46, ECP-51, INO80J, REPTIN, TIP49B, TAP54-beta, Reptin/RUVBL2
Positive Sample:BT-474, K-562, SW480, MCF7
Cellular Localization:Cytoplasm, Membrane, Nucleus, Nucleus Matrix, Nucleoplasm.
Calculated MW:51kDa
Observed MW:51kDa

This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.

Purification MethodAffinity purification
Gene ID10856
RRIDAB_2759406
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using Reptin/RUVBL2 Rabbit pAb (CAB12564) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
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