Epigenetics & Nuclear Signaling Antibodies 1

RRM1 Rabbit Polyclonal Antibody (CAB13348)

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SKU:
CAB13348
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
Reactivity:
Human, Mouse
Synonyms:
R1, RR1, RIR1, RRM1
Research Use:
Epigenetics and Nuclear Signaling
Frequently bought together:

Description

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RRM1 Antibody (CAB13348)

The RRM1 Antibody (CAB13348) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is highly specific for human samples and has been validated for Western blot applications. It binds to the RRM1 protein, allowing for precise detection and analysis in a variety of cell types.RRM1 is essential for maintaining genomic integrity and is often dysregulated in cancer cells, making it a promising target for cancer research. By targeting RRM1, researchers can gain insights into the mechanisms of tumorigenesis and potentially develop new therapeutic strategies.

This antibody is validated for use in WB, IF/ICC, IP, ELISA applications and has demonstrated reactivity against Human, Mouse samples.

Product Name:RRM1 Antibody
SKU:CAB13348
Size:20μL, 100μL
Reactivity:Human, Mouse
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:IRNS LLIA PMPT ASTA QILG NNES IEPY TSNI YTRR VLSG EFQI VNPH LLKD LTER GLWH EEMK NQII ACNG SIQS IPEI PDDL KQLY KTVW EISQ KTVL KMAA ERGA FIDQ SQSL NIHI AEPN YGKL TSMH FYGW KQGL KTGM YYLR TRPA ANPI QFTL NKEK LKDK EKVS KEEE EKER NTAA MVCS LENR DECL MCGS
Tested Applications:WB IF/ICC IP ELISA
Recommended Dilution:
WB1:500 - 1:2000
IF/ICC1:50 - 1:200
IP0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:R1, RR1, RIR1, RRM1
Positive Sample:HeLa, SW480, 22Rv1, U-251MG, Mouse thymus, Mouse testis, Mouse spleen
Cellular Localization:Cytoplasm.
Calculated MW:90kDa
Observed MW:95kDa

This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants.

Purification MethodAffinity purification
Gene ID6240
RRIDAB_2760205
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using RAbGn1 Rabbit pAb (CAB13348) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Product ImageWestern blot analysis of various lysates using RAbGn1 Rabbit pAb (CAB13348) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Product ImageImmunofluorescence analysis of HeLa cells using RAbGn1 Rabbit pAb (CAB13348) at dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
Product ImageImmunoprecipitation analysis of 200 μg extracts of HeLa cells using 1 μg RAbGn1 antibody (CAB13348). Western blot was performed from the immunoprecipitate using RAbGn1 antibody (CAB13348) at a dilution of 1:500.
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