Cell Biology Antibodies 7

Anti-PRDX1 Antibody (CAB16412)

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SKU:
CAB16412
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PRDX1 Antibody
Antibody SKU:CAB16412
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human PRDX1 (NP_001189360.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Rat
Positive Samples:Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human PRDX1 (NP_001189360.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSSG NAKI GHPA PNFK ATAV MPDG QFKD ISLS DYKG KYVV FFFY PLDF TFVC PTEI IAFS DRAE EFKK LNCQ VIGA SVDS HFCH LAWV NTPK KQGG LGPM NIPL VSDP KRTI AQDY GVLK ADEG ISFR GLFI IDDK GILR QITV NDLP VGRS VDET LRLV QAFQ FTDK HGEV CPAG WKPG SDTI KPDV QKSK EYFS KQK
Gene ID:5052
Uniprot:Q06830
Cellular Location:Cytoplasm, Melanosome
Calculated MW:22kDa
Observed MW:22kDa
Synonyms:PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2
Background:This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene.
UniProt Protein Function:PRDX1: a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). May have a proliferative effect and play a role in cancer development or progression.
UniProt Protein Details:

Protein type:Nuclear receptor co-regulator; Oxidoreductase; EC 1.11.1.15

Chromosomal Location of Human Ortholog: 1p34.1

Cellular Component: peroxisomal matrix; extracellular space; mitochondrial matrix; cytoplasm; nucleolus; melanosome; nucleus; cytosol

Molecular Function:protein binding; peroxidase activity; protein homodimerization activity; thioredoxin peroxidase activity; heme binding

Biological Process: cell proliferation; retinal homeostasis; erythrocyte homeostasis; regulation of stress-activated MAPK cascade; response to reactive oxygen species; removal of superoxide radicals; hydrogen peroxide catabolic process; natural killer cell mediated cytotoxicity; skeletal development; regulation of NF-kappaB import into nucleus

NCBI Summary:This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]
UniProt Code:Q06830
NCBI GenInfo Identifier:548453
NCBI Gene ID:5052
NCBI Accession:Q06830.1
UniProt Related Accession:Q06830
Molecular Weight:
NCBI Full Name:Peroxiredoxin-1
NCBI Synonym Full Names:peroxiredoxin 1
NCBI Official Symbol:PRDX1  
NCBI Official Synonym Symbols:PAG; PAGA; PAGB; PRX1; PRXI; MSP23; NKEFA; TDPX2; NKEF-A  
NCBI Protein Information:peroxiredoxin-1
UniProt Protein Name:Peroxiredoxin-1
UniProt Synonym Protein Names:Natural killer cell-enhancing factor A; NKEF-A; Proliferation-associated gene protein; PAG; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2
UniProt Gene Name:PRDX1  
UniProt Entry Name:PRDX1_HUMAN
Anti-PRDX1 Antibody (CAB16412)Western blot analysis of extracts of rat liver, using PRDX1 antibody (CAB16412) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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