Cell Biology Antibodies 5

PICK1 Rabbit Polyclonal Antibody (CAB1519)

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SKU:
CAB1519
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Synonyms:
PICK, PRKCABP, PICK1
Research Use:
Cell Biology
Frequently bought together:

Description

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PICK1 Antibody (CAB1519)

The PICK1 Antibody (CAB1519) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, exhibits high specificity and sensitivity when detecting Pick1 in various experimental settings, including immunofluorescence and Western blot analysis.Pick1 is a crucial protein in the brain, where it regulates the trafficking and localization of neurotransmitter receptors, such as AMPA receptors, contributing to synaptic plasticity and memory formation. Dysregulation of Pick1 has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease, making it an attractive target for therapeutic interventions.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.

Product Name:PICK1 Antibody
SKU:CAB1519
Size:20μL, 100μL
Reactivity:Human
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:CRQE ARAR FSQM RKDV LEKM ELLD QKHV QDIV FQLQ RLVS TMSK YYND CYAV LRDA DVFP IEVD LAHT TLAY GLNQ EEFT DGEE EEEE EDTA AGEP SRDT R
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:PICK, PRKCABP, PICK1
Positive Sample:HL-60, Jurkat, K-562, SH-SY5Y, HT-29, SW620
Cellular Localization:Cell Junction, Cytoplasm, Lipid-Anchor, Membrane, Peripheral Membrane Protein, Cytoskeleton, Perinuclear Region, Postsynaptic Cell Membrane, Postsynaptic Density, Synapse, Synaptosome.
Calculated MW:47kDa
Observed MW:53kDa

The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.

Purification MethodAffinity purification
Gene ID9463
RRIDAB_2762081
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using PICK1 Rabbit pAb (CAB1519) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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