Developmental Biology

PBX1 Rabbit Polyclonal Antibody (CAB7567)

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SKU:
CAB7567
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology
Reactivity:
Human, Mouse, Rat
Synonyms:
CAKUHED, PBX1
Research Use:
Developmental Biology
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Description

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PBX1 Antibody (CAB7567)

The PBX1 Antibody (CAB7567) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.PBX1 is known to regulate gene expression and play a key role in cell differentiation and proliferation. Dysregulation of PBX1 has been implicated in various diseases, particularly cancers, making it an attractive target for therapeutic interventions.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:PBX1 Antibody
SKU:CAB7567
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:VTAT NVSA HGSQ ANSP STPN SAGS SSSF NMSN SGDL FMSV QSLN GDSY QGAQ VGAN VQSQ VDTL RHVI SQTG GYSD GLAA SQMY SPQG ISAN GGWQ DATT PSSV TSPT EGPG SVHS DTSN
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:1000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:CAKUHED, PBX1
Positive Sample:A-431, HeLa, , Mouse brain, Rat brain
Cellular Localization:Nucleus.
Calculated MW:47kDa
Observed MW:42kDa/52kDa

This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Purification MethodAffinity purification
Gene ID5087
RRIDAB_2768090
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates, using PBX1 Rabbit pAb (CAB7567) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
Product ImageWestern blot analysis of lysates from Rat brain, using PBX1 Rabbit pAb (CAB7567) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 20s.
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