Cell Death Antibodies 2

NLRP2 Rabbit Polyclonal Antibody (CAB8233)

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SKU:
CAB8233
Product Type:
Antibody
Applications:
WB
Applications:
IF
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death
Antibody Type:
Polyclonal Antibody
Reactivity:
Human, Mouse
Synonyms:
NBS1, PAN1, NALP2, PYPAF2, CLR19.9, NLRP2
Research Use:
Cell Death
Frequently bought together:

Description

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NLRP2 Antibody (CAB8233)

The NLRP2 Antibody (CAB8233) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is highly specific for detecting NLRP2 in human samples and has been validated for use in Western blot applications.NLRP2 plays a key role in the regulation of inflammatory responses and immune signaling pathways, making it a promising target for research in areas such as immunology, infectious diseases, and inflammatory disorders.

This antibody is validated for use in WB, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse samples.

Product Name:NLRP2 Antibody
SKU:CAB8233
Size:20μL, 100μL
Reactivity:Human, Mouse
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:NVTA SESD AEVE RSQD DQHM LPFW TDLC SIFG SNKD LMGL AIND SFLS ASLV RILC EQIA SDTC HLQR VVFK NISP ADAH RNLC LALR GHKT VTYL TLQG NDQD DMFP ALCE VLRH PECN LRYL GLVS CSAT TQQW ADLS LALE VNQS LTCV NLSD
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:1000
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:NBS1, PAN1, NALP2, PYPAF2, CLR19.9, NLRP2
Positive Sample:HT-29, 293T
Cellular Localization:Cytoplasm.
Calculated MW:121kDa
Observed MW:120kDa

This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms.

Purification MethodAffinity purification
Gene ID55655
RRIDAB_2770599
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using NLRP2 Rabbit pAb (CAB8233) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
Product ImageImmunofluorescence analysis of NIH/3T3 cells using NLRP2 Rabbit pAb (CAB8233) at dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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