Immunology Antibodies 2

NLRP1 Rabbit Polyclonal Antibody (CAB16212)

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SKU:
CAB16212
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
Reactivity:
Human, Mouse, Rat
Synonyms:
NAC, JRRP, MSPC, AIADK, CARD7, CIDED, NALP1, SLEV1, DEFCAP, PP1044, VAMAS1, CLR17.1, DEFCAP-L/S, NLRP1
Research Use:
Immunology
Frequently bought together:

Description

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NLRP1 Antibody (CAB16212)

The NLRP1 Antibody (CAB16212) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to NLRP1, researchers can accurately detect and analyze the protein in various cell types, making it an essential tool for investigations in immunology, infectious diseases, and inflammation.NLRP1 is a critical component of the inflammasome, a multiprotein complex responsible for initiating inflammatory responses in the presence of pathogens or cellular stress.

This antibody is validated for use in WB, IHC-P, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:NLRP1 Antibody
SKU:CAB16212
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:PSPL DAPQ LLHF VDQY REQL IARV TSVE VVLD KLHG QVLS QEQY ERVL AENT RPSQ MRKL FSLS QSWD RKCK DGLY QALK ETHP HLIM ELWE KGSK KGLL PLSS
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:1000
IHC-P1:50 - 1:200
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:NAC, JRRP, MSPC, AIADK, CARD7, CIDED, NALP1, SLEV1, DEFCAP, PP1044, VAMAS1, CLR17.1, DEFCAP-L/S, NLRP1
Positive Sample:K-562
Cellular Localization:Cytoplasm, Cytosol, Inflammasome Complex, Nlrp1 Inflammasome Complex, Nucleolus, Nucleoplasm, Nucleus.
Calculated MW:166kDa
Observed MW:160kDa

This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.

Purification MethodAffinity purification
Gene ID22861
RRIDAB_2763666
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of lysates from K-562 cells, using NLRP1 Rabbit pAb (CAB16212) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 180s.
Product ImageImmunohistochemistry analysis of paraffin-embedded Human colon using NLRP1 Rabbit pAb (CAB16212) at dilution of 1:50 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
Product ImageImmunofluorescence analysis of K-562 cells using NLRP1 Rabbit pAb (CAB16212) at dilution of 1:50 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
Product ImageImmunofluorescence analysis of PC-12 cells using NLRP1 Rabbit pAb (CAB16212) at dilution of 1:50 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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