Cell Biology Antibodies 4

MSLN Rabbit Polyclonal Antibody (CAB14099)

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SKU:
CAB14099
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Reactivity:
Human, Mouse, Rat
Synonyms:
MPF, SMRP, Mesothelin
Research Use:
Cell Biology
Frequently bought together:

Description

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MSLN Antibody (CAB14099)

The MSLN Antibody (CAB14099) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, raised in rabbits, is highly specific to human MSLN samples and is validated for use in applications such as Western blotting.Mesothelin is a cell surface protein that is overexpressed in various types of cancer, including mesothelioma, ovarian cancer, and pancreatic cancer. By targeting MSLN, researchers can better understand the mechanisms behind tumor growth and potentially develop new therapies targeting this protein.

This antibody is validated for use in WB, IHC-P, ELISA, IF-P applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:MSLN Antibody
SKU:CAB14099
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:EVEK TACP SGKK AREI DESL IFYK KWEL EACV DAAL LATQ MDRV NAIP FTYE QLDV LKHK LDEL YPQG YPES VIQH LGYL FLKM SPED IRKW NVTS LETL KALL EVNK GHEM SPQA PRRP LPQV ATLI DRFV KGRG QLDK DTLD TLTA FYPG YLCS LSPE ELSS VPPS SIWA VRPQ DLDT CDPR QLDV LYPK ARLA FQNM NGSE YFVK IQSF LGGA PTED LKAL SQQN VSMD LATF MKLR TDAV LPLT VAEV QKLL GPHV EGLK AEER HRPV RDWI LRQR QDDL DTLG LGLQ GGIP NGYL VLDL SMQE ALS
Tested Applications:WB IHC-P ELISA IF-P
Recommended Dilution:
WB1:1000 - 1:5000
IF-P1:100 - 1:500
IHC-P1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:MPF, SMRP, Mesothelin
Positive Sample:OVCAR3
Cellular Localization:Cell Membrane, Gpi-Anchor, Golgi Apparatus, Lipid-Anchor, Secreted.
Calculated MW:69kDa
Observed MW:46-48kDa/70kDa

This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Purification MethodAffinity purification
Gene ID10232
RRIDAB_2760954
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of lysates from OVCAR3 cells, using Mesothelin Rabbit pAb (CAB14099) at 1:2000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
Product ImageImmunohistochemistry analysis of paraffin-embedded Human lung cancer（200X） using Mesothelin Rabbit pAb (CAB14099) at dilution of 1:50 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
Product ImageImmunohistochemistry analysis of paraffin-embedded Human tonsil（200X） using Mesothelin Rabbit pAb (CAB14099) at dilution of 1:50 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
Product ImageImmunohistochemistry analysis of paraffin-embedded Human tonsil（400X） using Mesothelin Rabbit pAb (CAB14099) at dilution of 1:50 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
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