Anti-mGluR1/5 Antibody [N75/33 (Formerly sold as S75-33)]

mGluR1/5 Antibody [N75/33 (Formerly sold as S75-33)]

mGluR1/5 Antibody [N75/33 (Formerly sold as S75-33)] is a mouse monoclonal antibody directed against mGluR1/5, offered by Assay Genie for research applications. Reported applications include WB, IHC, ICC/IF and IP. Reported reactivity: Human, Mouse and Rat. Supplied as IgG1, purified by Protein G.

Metabotropic glutamate receptor 5 (mGluR5) is a G-protein-coupled receptor that modulates excitatory neurotransmission and synaptic plasticity in the central nervous system. It plays a critical role in learning, memory, and neurodevelopment. Dysregulation of mGluR5 signaling has been implicated in a range of neurodegenerative and neuropsychiatric disorders, including Alzheimer’s disease, Huntington’s disease, and fragile X syndrome. Overactivation of mGluR5 can lead to excitotoxicity, neuroinflammation, and synaptic dysfunction. Conversely, pharmacological inhibition of mGluR5 has shown neuroprotective effects in preclinical models by reducing amyloid-beta accumulation, restoring synaptic function, and attenuating cognitive deficits. As a modulator of glutamatergic signaling, mGluR5 represents a promising therapeutic target for restoring neural circuit balance and preventing neurodegenerative progression. Ongoing clinical trials are evaluating mGluR5 antagonists for their efficacy in treating cognitive and behavioral symptoms associated with neurodegeneration. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.