LRP4 Antibody [N207/27 (Formerly sold as S207-27)]
LRP4 Antibody [N207/27 (Formerly sold as S207-27)] is a mouse recombinant monoclonal antibody directed against LRP4, offered by Assay Genie for research applications. Reported applications include WB and ICC/IF. Reported reactivity: Human, Mouse and Rat. Supplied as IgG2A, purified by Protein G.
LRP4 (Low-Density Lipoprotein Receptor-Related Protein 4) is a transmembrane receptor essential for neuromuscular junction formation and synaptic signaling. It acts as a co-receptor for agrin and MuSK, facilitating synapse development and maintenance. In the central nervous system, LRP4 influences astrocyte-neuron communication and synaptic plasticity. Mutations or autoantibodies targeting LRP4 are linked to myasthenia gravis and may contribute to cognitive dysfunction. Emerging evidence suggests LRP4 plays a role in neurodegenerative diseases by modulating synaptic integrity and glial function. Its involvement in both peripheral and central synaptic regulation positions LRP4 as a promising target for therapeutic intervention in neuromuscular and neurodegenerative disorders. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
LRP4 Antibody [N207/27 (Formerly sold as S207-27)]
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, ICC/IF
Antibody Isotype:
IgG2A
Purification:
Protein G Purified
Concentration:
1 mg/ml
Reactivity:
Human, Mouse, Rat
Recommended Dilution:
WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Specificity:
Detects the extracellular domain of LRP4 ~215kDa. Degradation product can be seen at ~150kDa.
Guarantee:
12 months from date of dispatch
Immunogen:
Fusion protein amino acids 26- 350 (extracellular N-terminus) of mouse LTP4
Immunogen Species:
Mouse
Accession Number:
NP_766256.3
Gene ID:
2128-07-11 00:00:00
Swiss-Prot:
Q8VI56
Cellular Localization:
Membrane
Alternative Names:
LRP4, LRP-4, LRP10, MEGF7, Low density lipoprotein receptor related protein 4, Multiple epidermal growth factor like domains 7, LDLR dan, LDLR, KIAA0816, Corin
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