Signal Transduction Antibodies 2

KCNQ1 Rabbit Polyclonal Antibody (CAB2174)

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SKU:
CAB2174
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction
Antibody Type:
Polyclonal Antibody
Reactivity:
Human, Mouse, Rat
Synonyms:
LQT, RWS, WRS, LQT1, SQT2, ATFB1, ATFB3, JLNS1, KCNA8, KCNA9, Kv1.9, Kv7.1, KVLQT1, KCNQ1
Research Use:
Signal Transduction
Frequently bought together:

Description

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KCNQ1 Antibody (CAB2174)

The KCNQ1 Antibody (CAB2174) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.KCNQ1 is essential for maintaining the electrical activity of the heart and mutations in this gene have been associated with various cardiac disorders, including Long QT syndrome. The KCNQ1 Polyclonal Antibody binds specifically to the KCNQ1 protein, allowing for accurate detection and analysis in a variety of cell types.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:KCNQ1 Antibody
SKU:CAB2174
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:TAWR CYAA ENPD SSTW KIYI RKAP RSHT LLSP SPKP KKSV VVKK KKFK LDKD NGVT PGEK MLTV PHIT CDPP EERR LDHF SVDG YDSS VRKS PTLL EVSM PHFM RTNS FAED LDLE GETL LTPI THIS QLRE HHRA TIKV IRRM QYFV AKKK FQQA RKPY DVRD VIEQ YSQG HLNL MVRI KELQ RRLD QSIG KPSL FISV SEKS KDRG SNTI GARL NRVE DKVT QLDQ RLAL ITDM LHQL LSLH GGST PGSG GPPR EGGA HITQ PCGS GGSV DPEL FLPS NTLP TYEQ LTVP RRGP DEGS
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:LQT, RWS, WRS, LQT1, SQT2, ATFB1, ATFB3, JLNS1, KCNA8, KCNA9, Kv1.9, Kv7.1, KVLQT1, KCNQ1
Positive Sample:293T, Mouse pancreas, Rat lung, Rat kidney, Rat heart
Cellular Localization:Cell Membrane, Cytoplasmic Vesicle Membrane, Multi-Pass Membrane Protein.
Calculated MW:75kDa
Observed MW:70kDa/75kDa

This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene.

Purification MethodAffinity purification
Gene ID3784
RRIDAB_2764192
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using KCNQ1 Rabbit pAb (CAB2174) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 10s.
Product ImageWestern blot analysis of various lysates using KCNQ1 Rabbit pAb (CAB2174) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 30s.
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