Anti-Kaiso/ZBTB33 Antibody (CAB3770)

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SKU:
CAB3770
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ZNF-kaiso
Synonyms:
ZNF348
Research Area:
Epigenetics and Nuclear Signaling

Description

Product Name:Kaiso/ZBTB33 Rabbit mAb
Product Code:CAB3770
Size:20uL, 50uL, 100uL
Synonyms:ZNF-kaiso, ZNF348
Applications:WB, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Kaiso/ZBTB33
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, SH-SY5Y, Rat brain
Immunogen:A synthesized peptide derived from human Kaiso/ZBTB33
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10009
Uniprot:Q86T24
Calculated MW:85kDa
Observed MW:74KDa
UniProt Protein Function:Kaiso: Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2.
UniProt Protein Details:

Protein type:C2H2-type zinc finger protein; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: Xq24

Cellular Component: cytosol; nucleolus; nucleoplasm; nucleus; plasma membrane

Molecular Function:methyl-CpG binding; protein binding; sequence-specific DNA binding

Biological Process: negative regulation of transcription, DNA-dependent

NCBI Summary:This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, May 2010]
UniProt Code:Q86T24
NCBI GenInfo Identifier:84029319
NCBI Gene ID:10009
NCBI Accession:Q86T24.2
UniProt Secondary Accession:Q86T24,O00319, Q7Z361, Q8IVP6, Q8N3P0, B2R5U6,
UniProt Related Accession:Q86T24
Molecular Weight:74kDa
NCBI Full Name:Transcriptional regulator Kaiso
NCBI Synonym Full Names:zinc finger and BTB domain containing 33
NCBI Official Symbol:ZBTB33  
NCBI Official Synonym Symbols:ZNF348; ZNF-kaiso  
NCBI Protein Information:transcriptional regulator Kaiso
UniProt Protein Name:Transcriptional regulator Kaiso
UniProt Synonym Protein Names:Zinc finger and BTB domain-containing protein 33
Protein Family:Transcriptional regulator
UniProt Gene Name:ZBTB33  
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