Cell Biology Antibodies 18

IPO7 Rabbit Polyclonal Antibody (CAB18417)

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SKU:
CAB18417
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
Antibody Type:
Polyclonal Antibody
Reactivity:
Human, Mouse, Rat
Synonyms:
Imp7, RANBP7, IPO7
Research Use:
Cell Biology
Frequently bought together:

Description

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IPO7 Antibody (CAB18417)

The IPO7 Antibody (CAB18417) is a high-quality antibody developed for reliable detection and analysis of target proteins. Raised in rabbits, this antibody is highly specific for human samples and has been validated for use in Western blot applications. By binding to the IPO7 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it suitable for research in molecular biology, cell biology, and cancer biology.IPO7 plays a crucial role in the transport of proteins into the nucleus, a process essential for various cellular functions such as gene expression and cell signaling.

This antibody is validated for use in WB, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:IPO7 Antibody
SKU:CAB18417
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:ELGS DEDD IDED GQEY LEIL AKQA GEDG DDED WEED DAEE TALE GYST IIDD EDNP VDEY QIFK AIFQ TIQN RNPV WYQA LTHG LNEE QRKQ LQDI ATLA DQRR AAHE SKMI EKHG GYKF SAPV VPSS FNFG GPAP GMN
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:2000
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:Imp7, RANBP7, IPO7
Positive Sample:U-251MG, HepG2, HeLa, Mouse heart, Mouse brain, Rat brain
Cellular Localization:Cytosol, Nuclear Envelope, Nuclear Pore, Nucleoplasm.
Calculated MW:120kDa
Observed MW:130kDa

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.

Purification MethodAffinity purification
Gene ID10527
RRIDAB_2862184
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using IPO7 Rabbit pAb (CAB18417) at 1:2000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
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