Cell Biology Antibodies 13

INPP5E Rabbit Polyclonal Antibody (CAB17735)

(No reviews yet) Write a Review
SKU:
CAB17735
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Reactivity:
Human, Mouse, Rat
Synonyms:
CPD4, CORS1, JBTS1, MORMS, PPI5PIV, pharbin, INPP5E
Research Use:
Cell Biology
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS

INPP5E Antibody (CAB17735)

The INPP5E Antibody (CAB17735) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the INPP5E protein, this antibody allows for the detection and analysis of INPP5E in various cell types, making it ideal for studies in cell biology and molecular signaling pathways.INPP5E is involved in the regulation of phosphoinositide metabolism, which is essential for various cellular processes such as membrane trafficking, cell growth, and cell survival.

This antibody is validated for use in WB, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:INPP5E Antibody
SKU:CAB17735
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:LIRE MRKG SIFK GFQE PDIH FLPS YKFD IGKD TYDS TSKQ RTPS YTDR VLYR SRHK GDIC PVSY SSCP GIKT SDHR PVYG LFRV KVRP GRDN IPLA AGKF DREL YLLG IKRR ISKE IQRQ Q
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:2000
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:CPD4, CORS1, JBTS1, MORMS, PPI5PIV, pharbin, INPP5E
Positive Sample:SH-SY5Y
Cellular Localization:Axoneme, Cilium, Cytosol, Focal Adhesion, Golgi Apparatus, Nucleoplasm, Nucleus, Plasma Membrane.
Calculated MW:70kDa
Observed MW:80kDa

The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms.

Purification MethodAffinity purification
Gene ID56623
RRIDAB_2769980
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from SH-SY5Y cells, using INPP5E Rabbit pAb (CAB17735) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 3s.
Product ImageImmunofluorescence analysis of C6 cells using INPP5E Rabbit pAb (CAB17735) at dilution of 1:100. Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
View AllClose

0 Reviews

View AllClose

Related Products