Metabolism Antibodies 2

HSD17B3 Rabbit Polyclonal Antibody (CAB7687)

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SKU:
CAB7687
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
Reactivity:
Human, Mouse, Rat
Synonyms:
EDH17B3, SDR12C2, HSD17B3
Research Use:
Metabolism
Frequently bought together:

Description

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HSD17B3 Antibody (CAB7687)

The HSD17B3 Antibody (CAB7687) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated from rabbit immunizations, specifically targets HSD17B3 in human samples and is validated for use in Western blot assays.HSD17B3 is a key enzyme in the conversion of estrone to estradiol, a process involved in hormone production and regulation. Dysregulation of HSD17B3 activity has been implicated in various hormone-related disorders, including hormone-dependent cancers and metabolic diseases.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:HSD17B3 Antibody
SKU:CAB7687
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:MGDV LEQF FILT GLLV CLAC LAKC VRFS RCVL LNYW KVLP KSFL RSMG QWAV ITGA GDGI GKAY SFEL AKRG LNVV LISR TLEK LEAI ATEI ERTT GRSV KIIQ ADFT KDDI YEHI KEKL AGLE IGIL VNNV GMLP NLLP SHFL NAPD EIQS LIHC NITS VVKM TQLI LKHM ESRQ KGLI LNIS SGIA LFPW PLYS MYSA SKAF VCAF SKAL QEEY KAKE VIIQ VLTP YAVS TAMT KYLN TNVI TKTA DEFV KESL NYVT IGGE TCGC LAHE ILAG FLSL IPAW AFYS GAFQ RLLL THYV AYLK LNTK VR
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:EDH17B3, SDR12C2, HSD17B3
Positive Sample:293T transfected with HSD17B3
Cellular Localization:Endoplasmic Reticulum.
Calculated MW:35kDa
Observed MW:33kDa

This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia.

Purification MethodAffinity purification
Gene ID3293
RRIDAB_2769877
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of lysates from wild type (WT) and 293T cells transfected with HSD17B3 using HSD17B3 Rabbit pAb (CAB7687) at 1:2500 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
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