Cell Biology Antibodies 9

GHRH Rabbit Polyclonal Antibody (CAB5343)

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SKU:
CAB5343
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Reactivity:
Human, Mouse, Rat
Synonyms:
GRF, INN, GHRF, GHRH
Research Use:
Cell Biology
Frequently bought together:

Description

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GHRH Antibody (CAB5343)

The GHRH Antibody (CAB5343) is a high-quality antibody developed for reliable detection and analysis of target proteins. This polyclonal antibody, raised in rabbits, is highly specific and reactive with human samples. It has been validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.Somatoliberin is a key regulator of growth hormone release from the pituitary gland, acting as a stimulator for growth hormone secretion. Dysregulation of somatoliberin signaling has been implicated in various growth disorders, including acromegaly and gigantism, as well as in certain types of cancer that rely on growth hormone signaling for proliferation.

This antibody is validated for use in WB, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:GHRH Antibody
SKU:CAB5343
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:FTNS YRKV LGQL SARK LLQ
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:1000
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:GRF, INN, GHRF, GHRH
Positive Sample:Mouse brain, Rat brain
Cellular Localization:Secreted.
Calculated MW:12kDa
Observed MW:12kDa

This gene encodes a member of the glucagon family of proteins. The encoded preproprotein is produced in the hypothalamus and cleaved to generate the mature factor, known as somatoliberin, which acts to stimulate growth hormone release from the pituitary gland. Variant receptors for somatoliberin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.

Purification MethodAffinity purification
Gene ID2691
RRIDAB_2766154
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using GHRH Rabbit pAb (CAB5343) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 180s.
Product ImageImmunofluorescence analysis of NTERA-2 cells using GHRH Rabbit pAb (CAB5343) at dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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