Cell Biology Antibodies 7

FBN1 Rabbit Polyclonal Antibody (CAB16677)

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SKU:
CAB16677
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Reactivity:
Human, Mouse, Rat
Synonyms:
FBN, SGS, WMS, MASS, MFLS, MFS1, OCTD, SSKS, WMS2, ACMICD, ECTOL1, GPHYSD2, Fibrillin 1
Research Use:
Cell Biology
  • FBN1 Rabbit Polyclonal Antibody (CAB16677)
  • FBN1 Rabbit Polyclonal Antibody (CAB16677)
  • FBN1 Rabbit Polyclonal Antibody (CAB16677)
  • FBN1 Rabbit Polyclonal Antibody (CAB16677)
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Description

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FBN1 Antibody (CAB16677)

The FBN1 Antibody (CAB16677) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is highly reactive with human samples and is validated for use in various applications, including Western blot and immunohistochemistry.Fibrillin-1 is a key component of microfibrils in connective tissues, playing a critical role in maintaining the structural integrity of tissues and organs. Mutations in the FBN1 gene are associated with various genetic disorders, including Marfan syndrome, highlighting the importance of studying this protein in both normal and pathological conditions.

This antibody is validated for use in WB, IHC-P, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:FBN1 Antibody
SKU:CAB16677
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:CDAG RCWS PGVT VAPE MCPI RATE DFNK LCSV PMVI PGRP EYPP PPLG PIPP VLPV PPGF PPGP QIPV PRPP VEYL YPSR EPPR VLPV NVTD YCQL VRYL C
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:1000
IHC-P1:50 - 1:200
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:FBN, SGS, WMS, MASS, MFLS, MFS1, OCTD, SSKS, WMS2, ACMICD, ECTOL1, GPHYSD2, Fibrillin 1
Positive Sample:Rat pancreas
Cellular Localization:Basement Membrane, Endoplasmic Reticulum Lumen, Extracellular Region, Extracellular Space.
Calculated MW:312kDa
Observed MW:312kDa

This gene encodes a member of the fibrillin family of proteins. The encoded preproprotein is proteolytically processed to generate two proteins including the extracellular matrix component fibrillin-1 and the protein hormone asprosin. Fibrillin-1 is an extracellular matrix glycoprotein that serves as a structural component of calcium-binding microfibrils. These microfibrils provide force-bearing structural support in elastic and nonelastic connective tissue throughout the body. Asprosin, secreted by white adipose tissue, has been shown to regulate glucose homeostasis. Mutations in this gene are associated with Marfan syndrome and the related MASS phenotype, as well as ectopia lentis syndrome, Weill-Marchesani syndrome, Shprintzen-Goldberg syndrome and neonatal progeroid syndrome.

Purification MethodAffinity purification
Gene ID2200
RRIDAB_2769423
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of lysates from Rat pancreas, using Fibrillin 1 Rabbit pAb (CAB16677) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
Product ImageImmunohistochemistry analysis of paraffin-embedded Human liver using Fibrillin 1 Rabbit pAb (CAB16677) at dilution of 1:50 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
Product ImageImmunofluorescence analysis of C6 cells using Fibrillin 1 Rabbit pAb (CAB16677) at dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
Product ImageImmunofluorescence analysis of NIH-3T3 cells using Fibrillin 1 Rabbit pAb (CAB16677) at dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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