Cell Biology Antibodies 14

EIF2B4 Rabbit Polyclonal Antibody (CAB18203)

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SKU:
CAB18203
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
Antibody Type:
Polyclonal Antibody
Reactivity:
Human, Mouse, Rat
Synonyms:
EIF2B, EIF-2B, EIF2Bdelta, EIF2B4
Research Use:
Cell Biology
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Description

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EIF2B4 Antibody (CAB18203)

The EIF2B4 Antibody (CAB18203) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for Western blot applications. By binding to the EIF2B4 protein, this antibody enables the detection and analysis of EIF2B4 in various cell types, facilitating investigations in molecular biology and cell signaling pathways.EIF2B4, a subunit of the eukaryotic translation initiation factor 2B (eIF2B) complex, plays a crucial role in the control of protein synthesis in response to cellular stress signals. Dysregulation of EIF2B4 has been associated with a variety of human diseases, including neurodegenerative disorders and certain types of cancer.

This antibody is validated for use in WB, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:EIF2B4 Antibody
SKU:CAB18203
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:EMTK EEKL QLRK EKKQ QKKK RKEE KGAE PETG SAVS AAQC QVGP TREL PESG IQLG TPRE KVPA GRSK AEL
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:2000
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:EIF2B, EIF-2B, EIF2Bdelta, EIF2B4
Positive Sample:Mouse brain, Rat testis, Rat brain
Cellular Localization:Cytoplasm, Cytosol, Eukaryotic Translation Initiation Factor 2B Complex.
Calculated MW:58kDa
Observed MW:57kDa

Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.

Purification MethodAffinity purification
Gene ID8890
RRIDAB_2861980
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using EIF2B4 Rabbit pAb (CAB18203) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
Product ImageImmunofluorescence analysis of L929 cells using EIF2B4 Rabbit pAb (CAB18203) at dilution of 1:100. Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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