Cell Death Antibodies 1

DYNLL1 Rabbit Polyclonal Antibody (CAB14496)

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SKU:
CAB14496
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
Reactivity:
Human, Mouse, Rat
Synonyms:
LC8, PIN, DLC1, DLC8, LC8a, DNCL1, hdlc1, DNCLC1, DYNLL1
Research Use:
Cell Death
Frequently bought together:

Description

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DYNLL1 Antibody (CAB14496)

The DYNLL1 Antibody (CAB14496) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, exhibits high specificity and reactivity towards human samples, making it ideal for use in Western blotting and immunofluorescence applications.Dynll1, also known as Dynein light chain 1, plays a crucial role in the regulation of dynein motor protein activity, which is essential for various cellular functions such as vesicle transport and mitotic spindle formation.

This antibody is validated for use in WB, IHC-P, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:DYNLL1 Antibody
SKU:CAB14496
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:MCDR KAVI KNAD MSEE MQQD SVEC ATQA LEKY NIEK DIAA HIKK EFDK KYNP TWHC IVGR NFGS YVTH ETKH FIYF YLGQ VAIL LFKS G
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:
WB1:500 - 1:1000
IHC-P1:50 - 1:200
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:LC8, PIN, DLC1, DLC8, LC8a, DNCL1, hdlc1, DNCLC1, DYNLL1
Positive Sample:HeLa, A-549, 293T, Rat brain
Cellular Localization:Cytoplasm, Mitochondrion, Nucleus, Cytoskeleton.
Calculated MW:10kDa
Observed MW:11kDa

Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.

Purification MethodAffinity purification
Gene ID8655
RRIDAB_2761370
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using DYNLL1 Rabbit pAb (CAB14496) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
Product ImageImmunohistochemistry analysis of paraffin-embedded Rat ovary using DYNLL1 Rabbit pAb (CAB14496) at dilution of 1:100 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
Product ImageImmunohistochemistry analysis of paraffin-embedded Mouse kidney using DYNLL1 Rabbit pAb (CAB14496) at dilution of 1:100 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
Product ImageImmunofluorescence analysis of C6 cells using DYNLL1 Rabbit pAb (CAB14496) at dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
Product ImageImmunofluorescence analysis of U-2 OS cells using DYNLL1 Rabbit pAb (CAB14496) at dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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