Cell Biology Antibodies 8

DOCK2 Rabbit Polyclonal Antibody (CAB3595)

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SKU:
CAB3595
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
Antibody Type:
Polyclonal Antibody
Reactivity:
Human, Mouse
Synonyms:
IMD40, DOCK2
Research Use:
Cell Biology
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Description

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DOCK2 Antibody (CAB3595)

The DOCK2 Antibody (CAB3595) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding to the Dock2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in immunology and cancer research.

This antibody is validated for use in WB, IF/ICC, IP, ELISA applications and has demonstrated reactivity against Human, Mouse samples.

Product Name:DOCK2 Antibody
SKU:CAB3595
Size:20μL, 100μL
Reactivity:Human, Mouse
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:FTEE YVRD HPED QDKL THLK DLIA WQIP FLGA GIKI HEKR VSDN LRPF HDRM EECF KNLK MKVE KEYG VREM PDFD DRRV GRPR SMLR SYRQ MSII SLAS MNSD CSTP SKPT SESF DLEL ASPK TPRV EQEE PISP GSTL PEVK LRRS KKRT KRSS VVFA DEKA AAES DLKR LSRK HEFM SDTN LSEH AAIP LKAS VLSQ MSFA SQSM PTIP ALAL SVAG IPGL DEAN TSPR LSQT FLQL SDGD KKTL TRKK VNQF FKTM LASK SAEE GKQI PDSL STDL
Tested Applications:WB IF/ICC IP ELISA
Recommended Dilution:
WB1:500 - 1:1000
IF/ICC1:50 - 1:200
IP0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:IMD40, DOCK2
Positive Sample:Jurkat
Cellular Localization:Cytoplasm, Endomembrane System, Peripheral Membrane Protein, Cytoskeleton.
Calculated MW:212kDa
Observed MW:240kDa

The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. Mutations in this gene result in immunodeficiency 40 (IMD40), a combined form of immunodeficiency that affects T cell number and function, also with variable defects in B cell and NK cell function.

Purification MethodAffinity purification
Gene ID1794
RRIDAB_2765171
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from Jurkat cells, using DOCK2 Rabbit pAb (CAB3595). Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Product ImageImmunofluorescence analysis of L929 cells using DOCK2 Rabbit pAb (CAB3595) at dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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