Cell Biology Antibodies 1

CRKL Rabbit Polyclonal Antibody (CAB0511)

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SKU:
CAB0511
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Reactivity:
Human, Mouse
Synonyms:
CRKL
Research Use:
Cell Biology
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Description

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CRKL Antibody (CAB0511)

The CRKL Antibody (CAB0511) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, demonstrates high specificity and sensitivity for detecting CRK-like protein in human samples, making it ideal for Western blot applications.CRK-like protein is a critical player in signaling pathways that regulate cell growth, survival, and motility. Dysregulation of CRK-like protein has been implicated in various diseases, including cancer, making it a promising target for therapeutic intervention.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.

Product Name:CRKL Antibody
SKU:CAB0511
Size:20μL, 100μL
Reactivity:Human, Mouse
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:PEPA HAYA QPQT TTPL PAVS GSPG AAIT PLPS TQNG PVFA KAIQ KRVP CAYD KTAL ALEV GDIV KVTR MNIN GQWE GEVN GRKG LFPF THVK IFDP QNPD
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:2000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:CRKL
Positive Sample:MCF7, HeLa, Raji, Mouse brain, Mouse thymus, Mouse liver
Cellular Localization:Cytosol, Extrinsic Component Of Postsynaptic Membrane, Neuromuscular Junction, Nucleoplasm.
Calculated MW:34kDa
Observed MW:34kDa

This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.

Purification MethodAffinity purification
Gene ID1399
RRIDAB_2757234
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using CRKL Rabbit pAb (CAB0511) at 1:500 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
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