Cell Biology Antibodies 12

Anti-COX7A2L Antibody (CAB8298)

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SKU:
CAB8298

Description

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Antibody Name:COX7A2L Rabbit Polyclonal Antibody
Antibody SKU:CAB8298
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human COX7A2L (NP_004709.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:MCF7, A-549, HeLa, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human COX7A2L (NP_004709.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MYYK FSGF TQKL AGAW ASEA YSPQ GLKP VVST EAPP IIFA TPTK LTSD STVY DYAG KNKV PELQ KFFQ KADG VPVY LKRG LPDQ MLYR TTMA LTVG GTIY CLIA LYMA SQPK NK
Gene ID:9167
Uniprot:O14548
Cellular Location:Mitochondrion inner membrane
Calculated MW:12kDa
Observed MW:13kDa
Synonyms:COX7A2L, COX7AR, COX7RP, EB1, SIG81
Background:Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene.
UniProt Protein Function:COX7A2L: May be a regulatory subunit of cytochrome c oxidase that mediates the higher level of energy production in target cells by estrogen. Belongs to the cytochrome c oxidase VIIa family.
UniProt Protein Details:

Protein type:Oxidoreductase; Mitochondrial; Energy Metabolism - oxidative phosphorylation

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: mitochondrial inner membrane

Biological Process: mitochondrial electron transport, cytochrome c to oxygen

NCBI Summary:Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]
UniProt Code:O14548
NCBI GenInfo Identifier:20141187
NCBI Gene ID:9167
NCBI Accession:O14548.2
UniProt Secondary Accession:O14548,Q9P118,
UniProt Related Accession:O14548
Molecular Weight:12,615 Da
NCBI Full Name:Cytochrome c oxidase subunit 7A-related protein, mitochondrial
NCBI Synonym Full Names:cytochrome c oxidase subunit 7A2 like
NCBI Official Symbol:COX7A2L  
NCBI Official Synonym Symbols:EB1; SIG81; COX7AR; COX7RP  
NCBI Protein Information:cytochrome c oxidase subunit 7A-related protein, mitochondrial
UniProt Protein Name:Cytochrome c oxidase subunit 7A-related protein, mitochondrial
UniProt Synonym Protein Names:COX7a-related protein; Cytochrome c oxidase subunit VIIa-related protein; EB1
Protein Family:Cytochrome c oxidase subunit 7A-related protein
UniProt Gene Name:COX7A2L  
UniProt Entry Name:COX7R_HUMAN
Anti-COX7A2L Polyclonal Antibody (CAB8298)Western blot analysis of extracts of various cell lines, using COX7A2L antibody (CAB8298) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
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Additional Information

Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
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