Cell Death Antibodies 2

COMP Rabbit Polyclonal Antibody (CAB5812)

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SKU:
CAB5812
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
Reactivity:
Human, Mouse, Rat
Synonyms:
MED, CTS2, EDM1, EPD1, TSP5, PSACH, THBS5, TSP-5, COMP
Research Use:
Cell Death
Frequently bought together:

Description

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COMP Antibody (CAB5812)

The COMP Antibody (CAB5812) is a high-quality antibody developed for reliable detection and analysis of target proteins. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and is optimized for Western blot applications. By targeting the COMP protein, this antibody enables the detection and analysis of COMP in various cell types, making it a valuable asset for investigations in the fields of musculoskeletal biology and cartilage development.COMP, also known as cartilage oligomeric matrix protein, plays a crucial role in maintaining the structural integrity of cartilage and other connective tissues.

This antibody is validated for use in WB, ELISA, IF-P applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:COMP Antibody
SKU:CAB5812
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:GQGQ SPLG SDLG PQML RELQ ETNA ALQD VREL LRQQ VREI TFLK NTVM ECDA CGMQ QSVR TGLP SVRP LLHC APGF CFPG VACI QTES GARC GPCP AGFT GNGS HCTD VNEC NAHP CFPR VRCI NTSP GFRC EACP PGYS G
Tested Applications:WB ELISA IF-P
Recommended Dilution:
WB1:500 - 1:5000
IF-P1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:MED, CTS2, EDM1, EPD1, TSP5, PSACH, THBS5, TSP-5, COMP
Positive Sample:SK-OV-3, U-2 OS, Mouse skeletal muscle, Mouse bone, Rat skeletal muscle
Cellular Localization:Secreted, Extracellular Matrix, Extracellular Space.
Calculated MW:83kDa
Observed MW:110kDa

The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).

Purification MethodAffinity purification
Gene ID1311
RRIDAB_2766564
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using COMP Rabbit pAb (CAB5812) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1s.
Product ImageWestern blot analysis of various lysates using COMP Rabbit pAb (CAB5812) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
Product ImageImmunofluorescence analysis of paraffin-embedded Mouse cartilage using COMP Rabbit pAb (CAB5812) at dilution of 1:200 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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