Cenexin1/ODF2 Rabbit Monoclonal Antibody (CAB3607)

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SKU:
CAB3607
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Developmental Biology
Synonyms:
CT134, ODF84, ODF2/1, ODF2/2, Cenexin1 / ODF2
Research Use:
Developmental Biology
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Description

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Cenexin1/ODF2 Monoclonal Antibody (CAB3607)

The Cenexin1/ODF2 Monoclonal Antibody (CAB3607) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody is specifically raised against Cenexin1 ODF2 and is highly reactive with human samples, making it a valuable tool for immunofluorescence and immunohistochemistry applications. Cenexin1 ODF2 is essential for the formation and function of centrioles, which play a critical role in cell division and cilia assembly. Dysregulation of Cenexin1 ODF2 has been linked to various diseases, including ciliopathies and cancer.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.

Product Name:Cenexin1/ODF2 Monoclonal Antibody
SKU:CAB3607
Size:20μL, 100μL
Reactivity:Human
Clone Number:ARC2057
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:KEHA LSKE RAAQ NKIL DLET QLSR TKTE LSQL RRSR DDAD RRYQ SRLQ DLKD RLEQ SEST NRSM QNYV QFLK SSYA NVFG DGPY STFL TSSP IRSR SPPA
Tested Applications:WB ELISA
Recommended Dilution:
WB1:1000 - 1:6000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:CT134, ODF84, ODF2/1, ODF2/2, Cenexin1 / ODF2
Positive Sample:HeLa, Hep G2, PC-3
Cellular Localization:Centriolar Subdistal Appendage, Centriole, Centrosome, Ciliary Basal Body, Ciliary Transition Fiber, Cilium, Cytosol, Nucleus, Sperm Flagellum, Spindle Pole.
Calculated MW:95kDa
Observed MW:95kDa

The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers.

Purification MethodAffinity purification
Gene ID4957
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using Cenexin1 / ODF2 Rabbit mAb (CAB3607) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
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