Name: ZAK Antibody (PACO04573)
SKU: PACO04573
Availability: OutOfStock

Antibody Name:	ZAK Antibody
Antibody SKU:	PACO04573
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB
Recommended Dilutions:	WB:1:500-1:2000
Species Reactivity:	Human, Mouse
Immunogen:	synthesized peptide derived from human MLTK around the non-phosphorylation site of S165.

Form:	Liquid
Storage Buffer:	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Synonyms:

MLTK; ZAK; HCCS4; Mitogen-activated protein kinase kinase kinase MLT; Human cervical cancer suppressor gene 4 protein; HCCS-4; Leucine zipper- and sterile alpha motif-containing kinase; MLK-like mitogen-activated protein triple kinase; Mixe

UniProt Protein Function:	ZAK: a mixed-lineage kinase containing a leucine-zipper (LZ) and a sterile-alpha motif (SAM). It is reported to activate the JNK/SAPK and NF-kappaB pathways.Protein type: Kinase, protein; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.25; TKL group; MLK family; MLK subfamilyChromosomal Location of Human Ortholog: 2q24.2Cellular Component: cytoplasm; nucleusMolecular Function: protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; magnesium ion binding; ATP bindingBiological Process: cell death; activation of MAPKK activity; positive regulation of apoptosis; cytoskeleton organization and biogenesis; protein amino acid phosphorylation; activation of JNK activity; cell proliferation; response to radiation; DNA damage checkpoint; response to stress; cell differentiation; cell cycle arrest; cell cycle checkpoint
UniProt Protein Details:
NCBI Summary:	This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9NYL2
NCBI GenInfo Identifier:	313104215
NCBI Gene ID:	51776
NCBI Accession:	Q9NYL2.3
UniProt Secondary Accession:	Q9NYL2,Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5 Q9HDD2, Q9NYE9, B3KPG2
UniProt Related Accession:	Q9NYL2
Molecular Weight:	800
NCBI Full Name:	Mitogen-activated protein kinase kinase kinase MLT
NCBI Synonym Full Names:
NCBI Official Symbol:	ZAK
NCBI Official Synonym Symbols:	pk; AZK; MLT; MRK; MLK7; MLTK; mlklak
NCBI Protein Information:	mitogen-activated protein kinase kinase kinase MLT; HCCS-4; mixed lineage kinase 7; mixed lineage kinase-related kinase MRK-beta; human cervical cancer suppressor gene 4 protein; MLK-like mitogen-activated protein triple kinase; mixed lineage kinase with a leucine zipper and a sterile alpha motif
UniProt Protein Name:	Mitogen-activated protein kinase kinase kinase MLT
UniProt Synonym Protein Names:	Human cervical cancer suppressor gene 4 protein; HCCS-4; Leucine zipper- and sterile alpha motif-containing kinase; MLK-like mitogen-activated protein triple kinase; Mixed lineage kinase-related kinase; MLK-related kinase; MRK; Sterile alpha motif- and leucine zipper-containing kinase AZK
Protein Family:	Mitogen-activated protein kinase kinase kinase
UniProt Gene Name:	ZAK
UniProt Entry Name:	MLTK_HUMAN