UniProt Protein Function: | ZAK: a mixed-lineage kinase containing a leucine-zipper (LZ) and a sterile-alpha motif (SAM). It is reported to activate the JNK/SAPK and NF-kappaB pathways.Protein type: Kinase, protein; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.25; TKL group; MLK family; MLK subfamilyChromosomal Location of Human Ortholog: 2q24.2Cellular Component: cytoplasm; nucleusMolecular Function: protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; magnesium ion binding; ATP bindingBiological Process: cell death; activation of MAPKK activity; positive regulation of apoptosis; cytoskeleton organization and biogenesis; protein amino acid phosphorylation; activation of JNK activity; cell proliferation; response to radiation; DNA damage checkpoint; response to stress; cell differentiation; cell cycle arrest; cell cycle checkpoint |
UniProt Protein Details: | |
NCBI Summary: | This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NYL2 |
NCBI GenInfo Identifier: | 313104215 |
NCBI Gene ID: | 51776 |
NCBI Accession: | Q9NYL2.3 |
UniProt Secondary Accession: | Q9NYL2,Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5 Q9HDD2, Q9NYE9, B3KPG2 |
UniProt Related Accession: | Q9NYL2 |
Molecular Weight: | 800 |
NCBI Full Name: | Mitogen-activated protein kinase kinase kinase MLT |
NCBI Synonym Full Names: | |
NCBI Official Symbol: | ZAK |
NCBI Official Synonym Symbols: | pk; AZK; MLT; MRK; MLK7; MLTK; mlklak |
NCBI Protein Information: | mitogen-activated protein kinase kinase kinase MLT; HCCS-4; mixed lineage kinase 7; mixed lineage kinase-related kinase MRK-beta; human cervical cancer suppressor gene 4 protein; MLK-like mitogen-activated protein triple kinase; mixed lineage kinase with a leucine zipper and a sterile alpha motif |
UniProt Protein Name: | Mitogen-activated protein kinase kinase kinase MLT |
UniProt Synonym Protein Names: | Human cervical cancer suppressor gene 4 protein; HCCS-4; Leucine zipper- and sterile alpha motif-containing kinase; MLK-like mitogen-activated protein triple kinase; Mixed lineage kinase-related kinase; MLK-related kinase; MRK; Sterile alpha motif- and leucine zipper-containing kinase AZK |
Protein Family: | Mitogen-activated protein kinase kinase kinase |
UniProt Gene Name: | ZAK |
UniProt Entry Name: | MLTK_HUMAN |